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Related Party Transactions (Details)
1 Months Ended 12 Months Ended 105 Months Ended
Jul. 07, 2015
USD ($)
Jul. 31, 2013
shares
Sep. 30, 2011
Apr. 30, 2007
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
$ / shares
shares
Dec. 31, 2013
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Jul. 31, 2015
USD ($)
Related Party Transaction                  
Restricted cash         $ 600,000 $ 4,438,000   $ 600,000  
Common stock warrants                  
Related Party Transaction                  
Number of shares of common stock under warrants issued to counterparty | shares         751,779 204,312 170,831 751,779  
Exercise price of warrants issued to counterparty (in dollars per share) | $ / shares         $ 10.30 $ 8.90 $ 8.00 $ 10.30  
Revenue share agreements                  
Related Party Transaction                  
Revenue share expense         $ 3,200,000 $ 2,300,000 $ 1,400,000    
Affiliate | Vertegen | License agreement                  
Related Party Transaction                  
Initial license fee paid       $ 10,000          
Initial royalty rate on net sales of products under the agreement (as a percent)         6.00%     6.00%  
Reduced royalty rate on net sales of products following expiration of patents (as a percent)         3.00%     3.00%  
Royalty payments               $ 0  
Expenses in connection with preparation of patent applications               140,000  
Affiliate | Vertegen | License agreement | United States                  
Related Party Transaction                  
Period for reduced royalty rate         5 years        
Affiliate | Vertegen | License agreement | Rest of World                  
Related Party Transaction                  
Period for reduced royalty rate         5 years        
Affiliate | Vertegen | License agreement | Common stock warrants                  
Related Party Transaction                  
Number of shares of common stock under warrants issued to counterparty | shares       100,000          
Exercise price of warrants issued to counterparty (in dollars per share) | $ / shares       $ 1.10          
Investor | Letter agreement | Asia                  
Related Party Transaction                  
Period after IPO for voluntary continuation of committee to direct investment of funds 2 years                
Proceeds reclassified from restricted cash to cash and cash equivalents                 $ 3,500,000
Restricted cash         $ 0 3,600,000   $ 0  
Investor | Letter agreement | Series E-1 and E-2 convertible preferred stock | Asia                  
Related Party Transaction                  
Original amount of proceeds from preferred stock issued to related party, restricted to use for marketing and sales in Asia $ 5,000,000                
Investor | Letter agreement | Series E-1 convertible preferred stock | Asia                  
Related Party Transaction                  
Preferred stock shares converted in exchange (in shares) | shares   381,875              
Investor | Letter agreement | Series E-2 convertible preferred stock | Asia                  
Related Party Transaction                  
Preferred stock shares issued in exchange (in shares) | shares   381,875              
Dr. Philipp Lang | Revenue share agreements                  
Related Party Transaction                  
Revenue share expense         $ 800,000 $ 600,000 $ 400,000    
Dr. Philipp Lang | Revenue share agreements | Minimum                  
Related Party Transaction                  
Required payment to related party from net revenues of current and planned products (as a percent)     0.875            
Dr. Philipp Lang | Revenue share agreements | Maximum                  
Related Party Transaction                  
Required payment to related party from net revenues of current and planned products (as a percent)     1.33