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Debt - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Oct. 06, 2021
Feb. 23, 2021
Mar. 05, 2019
Dec. 31, 2016
Mar. 31, 2022
Dec. 31, 2021
Aug. 03, 2018
May 31, 2018
Debt Instrument [Line Items]                
Face value of term loan         $ 30,000 $ 30,000    
Loan final repayment exit fees payable         $ (3,277) $ (3,277)    
Loan agreement, covenant noncompliance penalty         5.00%      
Loan agreement, covenant description         The loan includes customary events of default, including failure to pay amounts due, breaches of covenants and warranties, material adverse effect events, certain cross defaults and judgments, and insolvency      
Loan agreement, covenant compliance         and accelerate the maturity of the debt.      
Oxford Loan [Member]                
Debt Instrument [Line Items]                
Loan agreement, aggregate borrowing capacity       $ 25,000        
Loan, maturity period       Jul. 01, 2021        
Repayments of loan agreement exit fee         $ 900      
Oxford Loan [Member] | Tranche A [Member]                
Debt Instrument [Line Items]                
Face value of term loan       $ 15,000        
Amendment [Member] | Tranche B [Member]                
Debt Instrument [Line Items]                
Face value of term loan               $ 5,000
Amendment [Member] | Tranche C [Member]                
Debt Instrument [Line Items]                
Face value of term loan             $ 5,000  
Amended Oxford Loan [Member]                
Debt Instrument [Line Items]                
Loan agreement, aggregate borrowing capacity     $ 35,000          
Loan, maturity period         Mar. 01, 2024      
Loan outstanding     23,300          
Borrowings from loan agreement     6,700          
Loan agreement, floating rate terms         floating rate per annum equal to the greater of either the 30-day U.S. Dollar LIBOR reported in the Wall Street Journal plus 6.64% or 9.15%      
Percentage of exit fee on principal balance         7.50%      
Loan final repayment exit fees payable         $ 2,300      
Loan final repayment additional exit fees payable         $ 1,000      
Prepayment of loan fee, description         calculated as of the loan origination date, equal to (i) 2.0% of the loan prepaid during the first 12 months and (ii) 1.0% of the loan prepaid in months 13-24.      
Amended Oxford Loan [Member] | Loan Prepaid During First 12 Months [Member]                
Debt Instrument [Line Items]                
Debt instrument prepayment fee percentage         2.00%      
Amended Oxford Loan [Member] | Loan Prepaid During 13 to 24 Months [Member]                
Debt Instrument [Line Items]                
Debt instrument prepayment fee percentage         1.00%      
Amended Oxford Loan [Member] | Minimum [Member]                
Debt Instrument [Line Items]                
Loan agreement, interest rate 9.15%              
Amended Oxford Loan [Member] | Food and Drug Administration [Member]                
Debt Instrument [Line Items]                
Percentage of success fee         5.00%      
Success fees payable maximum period after approval         30 days      
Amended Oxford Loan [Member] | LIBOR [Member]                
Debt Instrument [Line Items]                
Loan agreement, percentage to be added to the interest rate under condition 6.64%              
Amended Oxford Loan [Member] | Amended Tranche A [Member]                
Debt Instrument [Line Items]                
Loan agreement, aggregate borrowing capacity     30,000          
Amended Oxford Loan [Member] | Amended Tranche A [Member] | Food and Drug Administration [Member]                
Debt Instrument [Line Items]                
Fee payable maximum period from funding         10 years      
Amended Oxford Loan [Member] | Amended Tranche B [Member]                
Debt Instrument [Line Items]                
Loan agreement, remaining borrowing capacity     $ 5,000          
Fifth Amended Oxford Loan [Member]                
Debt Instrument [Line Items]                
Principal and interest payment period   19 years            
Interest payment period   17 months            
Amendment fees payment   $ 200            
Fifth Amended Oxford Loan [Member] | Tranche B [Member]                
Debt Instrument [Line Items]                
Principal and interest payment period   13 years            
Interest payment period   6 months