Asset Purchase Agreements and Related License Agreements - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands			1 Months Ended		12 Months Ended
	Nov. 20, 2020	Mar. 22, 2016	Sep. 30, 2015	Dec. 31, 2010	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Asset Purchase Agreement And Related License Agreement [Line Items]
Compensation expense related to the time-vested/milestone vested options					$ 7,901	$ 5,973	$ 5,679
Milestone Vested Options [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Compensation expense related to the time-vested/milestone vested options					$ 0	0	0
Asset Purchase Agreement [Member] | EIG Transaction [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Upfront payment				$ 400
Asset purchase description					Within the first ten years after commercialization, the Company may make a one-time payment of $0.5 million for each contract for the three types of product related to such intellectual property that would reduce the payment term for the three products to the tenth anniversary of the first commercial sale.
One-time payment				$ 500
Asset Purchase Agreement [Member] | EIG Transaction [Member] | Farnesyl Transferase Inhibitors and Related Intellectual Property [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Royalties expiration description					The obligation to pay royalties expires on a country-by-country and product-by-product basis on the later of either when the product is no longer sold in any country or the earliest of the tenth anniversary of the first commercial sale of the product.
Avexitide Purchase Agreement [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Shares issued for purchased assets			15,378
Common stock, value			$ 200
Options to purchase common stock		48,544	46,134
Options to purchase of common stock exercise price		$ 17.25	$ 2.06
Options to purchase common stock vesting period			4 years
Vesting of options to purchase common stock			30,756
Compensation expense related to the time-vested/milestone vested options					$ 100	$ 100	$ 100
License agreement milestone payments paid					$ 100
Avexitide Purchase Agreement [Member] | Maximum [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Aggregate potential milestone payments			$ 1,000
AbbVie Asset Purchase Agreement [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Payment for asset purchase agreement	$ 95,000
AbbVie Asset Purchase Agreement [Member] | Progeria Research Foundation (PRF) Collaboration Agreement [Member]
Asset Purchase Agreement And Related License Agreement [Line Items]
Proceeds from sale	$ 46,500