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Stock Based Compensation - Fair Value of Stock Option Granted to Non-Employees Using Black-Scholes Option Pricing Model (Detail) - Non-Employees Stock Option [Member]
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Volatility, minimum 89.40% 88.50% 89.40% 88.10%
Volatility, maximum 95.80% 88.80% 95.80% 88.80%
Risk-free interest rate, minimum 1.40% 1.80% 1.40% 1.70%
Risk-free interest rate, maximum 1.90% 2.20% 2.00% 2.20%
Minimum [Member]        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Contractual term (in years) 7 years 3 months 8 years 3 months 7 years 3 months 8 years 3 months
Maximum [Member]        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Contractual term (in years) 9 years 11 months 1 day 8 years 5 months 1 day 10 years 8 years 8 months 1 day