X0306 4 2019-01-03 0 0001305253 Eiger BioPharmaceuticals, Inc. EIGR 0001762893 Ryali Sriram C/O EIGER BIOPHARMACEUTICALS, INC. 2155 PARK BLVD. PALO ALTO CA 94306 0 1 0 0 Chief Financial Officer Stock Option ( Right to Buy) 10.46 2019-01-03 4 A 0 90000 0.00 A 2029-01-02 Common Stock 90000 90000 D The option will vest as to 25% of the option shares on December 17, 2019 and vest as to the remaining shares in successive equal monthly installments for the subsequent 36 months subject to Reporting Person's continuous service status as of each such date. /s/ Sriram Ryali 2019-01-04