X0306 4 2022-03-11 0001305253 Eiger BioPharmaceuticals, Inc. EIGR 0001600361 Murray Christine C/O EIGER BIOPHARMACEUTICALS, INC. 2155 PARK BLVD. PALO ALTO CA 94306 true Common Stock 2022-03-11 4 A 0 6000 0 A 16000 D Stock Option (Right to Buy) 5.1 2022-03-11 4 A 0 12000 0 A 2032-03-10 Common Stock 12000 12000 D Represents shares underlying Restricted Stock Units award that will vest on the first anniversary of the grant date of March 11, 2022. The option vests in equal monthly installments over 12 months measured from March 11, 2022 subject to Reporting Person's continuous service status as of each such date. /s/ Sriram Ryali, Attorney-in-Fact 2022-03-11