X0306 4 2022-03-11 0001305253 Eiger BioPharmaceuticals, Inc. EIGR 0001670382 Glenn Jeffrey S C/O EIGER BIOPHARMACEUTICALS, INC. 2155 PARK BLVD. PALO ALTO CA 94306 true Common Stock 2022-03-11 4 A 0 6000 0 A 82355 D Common Stock 5000 I By spouse Common Stock 460 I By son Common Stock 151064 I By Eiger Group International, Inc. Stock Option (Right to Buy) 5.1 2022-03-11 4 A 0 12000 0 A 2032-03-10 Common Stock 12000 12000 D Represents shares underlying Restricted Stock Units award that will vest on the first anniversary of the grant date of March 11, 2022. Shares are held by Eiger Group International, Inc. ("EGI"). The Reporting Person is the Chief Executive Officer of EGI and has sole power to vote and sole power to dispose of shares directly owned by EGI. The Reporting Person disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein. The option vests in equal monthly installments over 12 months measured from March 11, 2022 subject to Reporting Person's continuous service status as of each such date. /s/ Sriram Ryali, Attorney-in-Fact 2022-03-11