144 0001304125 XXXXXXXX LIVE 0001484612 Outset Medical, Inc. 001-39513 3052 ORCHARD DRIVE SAN JOSE CA 95134 669-231-8200 Trigg Leslie Officer Common Stock Morgan Stanley Smith Barney LLC

1 New York Plaza, 38th Floor New York NY 10004

2120 10696.59 18153090 01/21/2026 NASDAQ Common Stock 01/17/2026 Settlement of Vested Restricted Stock Units Issuer N 32552 01/17/2026 Equity compensation for services rendered N Leslie Trigg

3052 Orchard Drive San Jose CA 95134

Common Stock 11/17/2025 916 4213.60 Leslie Trigg

3052 Orchard Drive San Jose CA 95134

Common 01/07/2026 1795 7664.65 Leslie Trigg

3052 Orchard Drive San Jose CA 95134

Common 01/20/2026 11794 60385.28 Shares sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. This sale was made to satisfy tax withholding obligations through a sell to cover transaction and does not represent a discretionary trade by the reporting person. 01/21/2026 John Brottem POA for Leslie Trigg