X0202 4 2007-02-26 0 0001012270 COLLAGENEX PHARMACEUTICALS INC CGPI 0001304113 Powell Andrew Kenneth William COLLAGENEX PHARMACEUTICALS, INC. 41 UNIVERSITY DRIVE, SUITE 200 NEWTOWN PA 18940 0 1 0 0 VP, G. Counsel and Corp. Sec. Options to Purchase Common Stock 14.28 2007-02-26 4 A 0 25000 0 A 2008-02-26 2017-02-25 Common Stock 25000 1257000 D Represents options granted by the Issuer pursuant to its 2005 Equity Incentive Plan on February 26, 2007. The options vest as follows: 5,000 shares subject to such options vest on February 26, 2008, 5,000 shares subject to such options vest on February 26, 2009, 5,000 shares subject to such options vest on February 26, 2010, 5,000 shares subject to such options vest on February 26, 2011 and 5,000 shares subject to such options vest on February 9, 2012. Includes multiple options grants with different prices and vesting dates. /s/ Andrew K.W. Powell 2007-03-08