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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 AUZs83NiHLkSWtOQ+hvW4UwtZyawN8WI47YVhx+ZR+gHZytc1GVizte9fzxug2zA
 KKoCQNMUKEMwzhs5DSji1Q==

<SEC-DOCUMENT>0001225208-08-019907.txt : 20081224
<SEC-HEADER>0001225208-08-019907.hdr.sgml : 20081224
<ACCEPTANCE-DATETIME>20081224143127
ACCESSION NUMBER:		0001225208-08-019907
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081215
FILED AS OF DATE:		20081224
DATE AS OF CHANGE:		20081224

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Coggin Michael S.
		CENTRAL INDEX KEY:			0001452622

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51251
		FILM NUMBER:		081270200

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		615-372-8500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT, SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIFEPOINT HOSPITALS, INC.
		CENTRAL INDEX KEY:			0001301611
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-GENERAL MEDICAL & SURGICAL HOSPITALS, NEC [8062]
		IRS NUMBER:				201538254
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
		BUSINESS PHONE:		615-372-8500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lakers Holding Corp.
		DATE OF NAME CHANGE:	20040826
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-12-15</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001301611</issuerCik>
        <issuerName>LIFEPOINT HOSPITALS, INC.</issuerName>
        <issuerTradingSymbol>LPNT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001452622</rptOwnerCik>
            <rptOwnerName>Coggin Michael S.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>103 POWELL COURT</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>BRENTWOOD</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Sr. VP &amp; Chief Acctg. Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Michael S. Coggin</signatureName>
        <signatureDate>2008-12-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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