Company and Nature of Business - Additional Information (Detail) - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Accumulated deficit	$ 738,694	$ 713,644
Cash and cash equivalents	47,980	69,587
Restricted cash	16,500
Short-term investments	$ 123,186	$ 138,636