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Acquisitions - Additional Information (Detail) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Jun. 27, 2019
Jun. 29, 2018
Sep. 30, 2019
Sep. 30, 2018
Jun. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Asset Acquisition [Line Items]                
Goodwill     $ 37,293     $ 37,293   $ 37,495
Research and development licensing fee satisfied with stock       $ 29,545 $ 2,000      
Research and development expenses     19,588 $ 51,202   62,570 $ 99,077  
Axis Therapeutics Limited                
Asset Acquisition [Line Items]                
Capital contributions to joint venture   $ 30,000 30,000     $ 30,000    
Percentage of ownership in joint venture   55.00%       55.00%    
Axis Therapeutics Limited | Research and Development Expenses                
Asset Acquisition [Line Items]                
Research and development expenses               $ 24,500
Axis Therapeutics Limited | Licensing Agreements                
Asset Acquisition [Line Items]                
Research and development licensing fee satisfied with stock, shares   267,952            
Research and development licensing fee satisfied with stock   $ 5,000            
Axis Therapeutics Limited | XLifeSc | IPR & D                
Asset Acquisition [Line Items]                
Percentage of ownership in joint venture   45.00%            
Percentage of nonmonetary exchange of shares           45.00%    
Fair value of equity shares issued     $ 24,500     $ 24,500    
Common Stock                
Asset Acquisition [Line Items]                
Research and development licensing fee satisfied with stock, shares       267,952 107,181      
CIDAL Limited                
Asset Acquisition [Line Items]                
Asset purchase agreement closing date Oct. 31, 2019              
Purchase price $ 2,200              
Liabilities assumed 1,100              
Contingent consideration paid 1,100              
Cash received 800              
Goodwill 1,400              
CIDAL Limited | Maximum [Member]                
Asset Acquisition [Line Items]                
Fixed assets $ 100              
CIDAL Limited | Common Stock                
Asset Acquisition [Line Items]                
Business acquisition, assumed liabilities and milestone payments aggregate share consideration 67,796