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Common stock shares held by related parties.

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Payments to related party for services received.

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Percentage of common stock issued shares.

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Purchase price per share..

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Carrying amount as of the balance sheet date of obligations due all related parties.

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Revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period.

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Revenue earned during the period relating to consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity.

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Total number of shares issued during the period, including shares forfeited, as a result of Restricted Stock Awards.

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Related Party Transactions - Additional Information (Details)	3 Months Ended			6 Months Ended		12 Months Ended
	Jun. 30, 2017 USD ($) shares	Mar. 31, 2017 USD ($) RelatedParty	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($) shares	Jun. 30, 2016 USD ($)	Dec. 31, 2016 USD ($) shares	Dec. 31, 2015 USD ($) $ / shares shares	Dec. 31, 2014 USD ($) $ / shares shares	Jun. 14, 2017 shares
Related Party Transaction [Line Items]
Stock-based compensation expense recognized	$ 6,676,000		$ 3,133,000	$ 8,820,000	$ 6,043,000
License fees and consulting revenue	98,000		71,000	696,000	166,000
Percentage of outstanding common stock holding		5.00%				5.00%
Convertible Bonds
Related Party Transaction [Line Items]
Amounts owed to related party	24,000,000	$ 4,000,000		24,000,000		$ 24,000,000
Amount purchased in convertible bonds by holders of outstanding common stock and entity affiliate		$ 2,000,000				$ 10,000,000
Number of related parties received convertible bonds \| RelatedParty		2
Bonds converted into shares of common stock \| shares									2,727,273
Restricted Stock
Related Party Transaction [Line Items]
Stock-based compensation expense recognized	540,000		1,120,000	$ 1,080,000	2,166,000
Executive Officer
Related Party Transaction [Line Items]
Shares of restricted stock sold on promissory notes \| shares				2,520,000			1,200,000	1,320,000
Amount of promissory notes signed to fund stock purchases							$ 6,600,000	$ 6,000,000
Notes receivable least period				3 years
Notes Receivable Description				The Company has accounted for this related party transaction as a restricted stock offering, recognizing as an expense the value of the vested shares and the forgiveness of the notes over the three-year period, contingent on the continued employment of the executive.
Stock-based compensation expense recognized	$ 0		1,000,000	$ 0	2,100,000
Executive Officer \| Restricted Stock
Related Party Transaction [Line Items]
Purchase price per share \| $ / shares							$ 5.50	$ 4.55
Avalon BioMedical
Related Party Transaction [Line Items]
Common stock shares held by related parties \| shares	678,880			678,880		678,880
Percentage of common stock issued shares				1.20%		1.70%
Avalon BioMedical \| CDE \| Research and Development Facility
Related Party Transaction [Line Items]
Percentage of rent payment				30.00%
Pharma Essentia
Related Party Transaction [Line Items]
Licenses revenue	$ 0		0	$ 500,000	0
Taisheng
Related Party Transaction [Line Items]
Purchases of pharmaceutical ingredients from related party	0		0	0	200,000
Amounts owed to related party	0			0		$ 0
ZenRx
Related Party Transaction [Line Items]
Amounts owed to related party	100,000			100,000
License fees and consulting revenue				0
ZenRx \| Maximum
Related Party Transaction [Line Items]
Amounts owed to related party						$ 100,000
ZenRx \| Clinical Development Services
Related Party Transaction [Line Items]
Payments to related party for services received	100,000			200,000
ZenRx \| Clinical Development Services \| Maximum
Related Party Transaction [Line Items]
Payments to related party for services received			100,000		100,000
RSJ Consulting LLC
Related Party Transaction [Line Items]
Consulting services incurred				$ 100,000	$ 200,000
RSJ Consulting LLC \| Maximum
Related Party Transaction [Line Items]
Consulting services incurred	$ 100,000		$ 100,000