X0407 4 2023-04-21 0 0001300699 Athenex, Inc. ATNX 0001708964 Fok Manson C/O ATHENEX, INC. 1001 MAIN STREET, SUITE 600 BUFFALO NY 14203 1 0 0 0 0 Common Stock 2023-04-21 4 A 0 5747 1.305 A 110675 D Common Stock 33944 I By Avalon Biomedical (Management) Limited Common Stock 5360 I By Avalon Polytom (HK) Limited Stock Option (Right to Buy) 91.00 2014-05-13 2023-05-13 Common Stock 2400 2400 D Stock Option (Right to Buy) 91.00 2015-10-11 2023-10-11 Common Stock 1000 1000 D Stock Option (Right to Buy) 91.00 2016-06-12 2024-06-12 Common Stock 2000 2000 D Stock Option (Right to Buy) 150.00 2016-05-18 2025-05-18 Common Stock 2400 2400 D Stock Option (Right to Buy) 180.00 2017-10-17 2025-10-17 Common Stock 2400 2400 D Stock Option (Right to Buy) 220.00 2021-06-13 2027-06-13 Common Stock 1350 1350 D Stock Option (Right to Buy) 180.00 2018-07-17 2025-07-17 Common Stock 2746 2746 I By Avalon Biomedical (Management) Limited Stock Option (Right to Buy) 346.00 2022-03-27 2028-03-27 Common Stock 750 750 D Stock Option (Right to Buy) 263.40 2023-02-28 2029-02-28 Common Stock 500 500 D Stock Option (Right to Buy) 249.00 2030-06-05 Common Stock 500 500 D Stock Option (Right to Buy) 76.00 2022-08-03 2031-08-03 Common Stock 313 313 D Stock Option (Right to Buy) 9.14 2032-06-28 Common Stock 625 625 D Shares purchased from the Issuer under a Salary Deduction and Stock Purchase Agreement at the Nasdaq Official Closing Price on the date of purchase. As of February 15, 2023, the issuer effected a reverse stock split of its common stock at a ratio of 1-for-20, resulting in every 20 shares owned by the reporting person to be combined into one share of common stock. Avalon Biomedical (Management) Limited ("Avalon Biomedical") is an indirect wholly-owned subsidiary of Avalon Global Holdings Limited ("Avalon Global"). Mason Fok, M.B., B.S. ("Dr. Fok"), together with his spouse, own all of the outstanding interests in Sino Glory Developments Limited, which owns 34.63% of the outstanding interests in Avalon Global, and Dr. Fok serves on the board of directors of Avalon Global and has shared voting and dispositive power with respect to the shares held by Avalon Biomedical. Dr. Fok disclaims beneficial ownership of the reported securities except to the extent, if any, of its or his pecuniary interest therein, and this report shall not be deemed an admission that Dr. Fok is the beneficial owner of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. These shares were acquired pursuant to the terms of a License Agreement dated as of June 29, 2018 by and between Athenex Therapeutics Limited, a wholly-owned subsidiary of Athenex, Inc. ("Athenex") and Avalon Polytom (HK) Limited, a majority-owned affiliate of Avalon Global. The number of shares was determined by dividing $2.0 million by the closing price of Athenex common stock on June 29, 2018. This option was adjusted to reflect the reverse stock split that occurred on February 15, 2023. This option vests in four equal annual installments beginning on June 5, 2021. This option vests on June 28, 2023. /s/ Staci Holquist, Attorney-in-Fact 2023-04-24