X0306 4 2023-02-24 0 0001300699 Athenex, Inc. ATNX 0001181165 LAU JOHNSON YIU NAM C/O ATHENEX, INC. 1001 MAIN STREET, SUITE 600 BUFFALO NY 14203 1 1 0 0 CEO and Chairman of the Board Common Stock 2023-02-24 4 A 0 1591 2.74 A 210215 D Common Stock 33944 I By Avalon Biomedical (Management) Limited Common Stock 8247 I By Spouse Common Stock 5360 I By Avalon Polytom (HK) Limited Stock Option (Right to Buy) 150.00 2018-05-22 2025-05-22 Common Stock 70000 70000 D Stock Option (Right to Buy) 220.00 2018-06-13 2027-06-13 Common Stock 1 1 D Stock Option (Right to Buy) 180.00 2019-07-17 2025-07-17 Common Stock 2746 2746 I By Avalon Biomedical (Management) Limited Stock Option (Right to Buy) 346.00 2022-03-27 2028-03-27 Common Stock 12500 12500 D Stock Option (Right to Buy) 263.40 2029-02-28 Common Stock 12500 12500 D Stock Option (Right to Buy) 146.40 2020-12-31 2030-03-24 Common Stock 2753 2753 D Stock Option (Right to Buy) 249.00 2030-06-05 Common Stock 15000 15000 D Stock Option (Right to Buy) 76.00 2031-08-03 Common Stock 7500 7500 D Restricted Stock Units Common Stock 5625 5625 D Stock Option (Right to Buy) 13.31 2032-07-20 Common Stock 12500 12500 D Shares purchased from the Issuer under a Salary Deduction and Stock Purchase Agreement at the Nasdaq Official Closing Price on the date of purchase. As of February 15, 2023, the issuer effected a reverse stock split of its common stock at a ratio of 1-for-20, resulting in every 20 shares owned by the reporting person to be combined into one share of common stock. Avalon Biomedical (Management) Limited ("Avalon Biomedical") is an indirect wholly-owned subsidiary of Avalon Global Holdings Limited ("Avalon Global"). Dr. Johnson Lau ("Dr. Lau") owns all of the outstanding interests in Creative Decade Global Limited, which owns 34.63% of the outstanding interests in Avalon Global, and Dr. Lau serves on the board of directors of Avalon Global and has shared voting and dispositive power with respect to the shares held by Avalon Biomedical. Dr. Lau disclaims beneficial ownership of the reported securities except to the extent, if any, of its or his pecuniary interest therein, and this report shall not be deemed an admission that Dr. Lau is the beneficial owner of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. These shares were acquired pursuant to the terms of a License Agreement dated as of June 29, 2018 by and between Athenex Therapeutics Limited, a wholly-owned subsidiary of Athenex, Inc. ("Athenex") and Avalon Polytom (HK) Limited, a majority-owned affiliate of Avalon Global. The number of shares was determined by dividing $2.0 million by the closing price of Athenex common stock on June 29, 2018. This option was adjusted to reflect the reverse stock split that occurred on February 15, 2023. This option vests in four equal annual installments beginning on February 28, 2020. This option vests in four equal annual installments beginning on June 5, 2021. This option vests in four equal annual installments beginning on August 3, 2022. Each restricted stock unit represents a contingent right to receive one share of stock. The restricted stock units vest in four equal annual installments beginning on August 3, 2022. The restricted stock units were adjusted to reflect the reverse stock split that occurred on February 15, 2023. This option vests in four equal annual installments beginning on July 20, 2023. /s/Steven Adams, Attorney-in-Fact 2023-02-27