Company and Nature of Business - Additional Information (Detail)						1 Months Ended		12 Months Ended
	Feb. 15, 2023	Jun. 29, 2022 USD ($)	Jun. 21, 2022 USD ($)	Jan. 19, 2022 USD ($) Tranche $ / shares	Jun. 19, 2020 USD ($) Tranche $ / shares shares	Aug. 31, 2022 USD ($) $ / shares shares	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($) Segment $ / shares shares	Dec. 31, 2021 USD ($) Segment $ / shares shares	Mar. 20, 2023 USD ($)	Sep. 30, 2022 USD ($)	Aug. 20, 2021 USD ($) $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of operating segments | Segment								2	3
Substantial doubt about going concern, conditions or events								The Company projects insufficient liquidity to fund its operations through the next twelve months beyond the date of the issuance of these consolidated financial statements. This condition raises substantial doubt about the Company’s ability to continue as a going concern. The Company is in compliance with the minimum liquidity and minimum revenue financial covenants in the Senior Credit Agreement as of December 31, 2022. However, the Company received notices of certain alleged defaults and reservations of rights related to the Senior Credit Agreement, as described in Note 12 - Debt and Lease Obligations, and is forecasting noncompliance with the minimum liquidity covenant and minimum revenue covenant included within the Senior Credit Agreement during the twelve month period subsequent to the date of this filing. Pursuant to ASC 205-40-50, the Company’s forecast and analysis herein does not reflect management’s plans that are outside of the Company’s control as described below. Violation of any covenant under the Senior Credit Agreement provides the lenders with the option to accelerate the maturity of the amounts due under the Senior Credit Agreement, which was $44.7 million as of December 31, 2022. Should the lenders accelerate the maturity of the amounts due under the Senior Credit Agreement, the Company would not have sufficient cash on hand or available liquidity to repay the outstanding debt. These conditions and events raise substantial doubt about the Company’s ability to continue as a going concern.
Substantial doubt about going concern, within next twelve month								true
Accumulated deficit								$ 1,016,839,000	$ 913,412,000
Cash and cash equivalents								30,437,000	35,202,000
Restricted Cash								5,200,000
Short-term investments								1,071,000	10,207,000
Common stock value								$ 9,000	$ 6,000
Common stock, par value (in dollars per share) | $ / shares								$ 0.001	$ 0.001
Royalty financing liability								$ 86,745,000
License And Development Agreement With Almairall S.A.
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Milestone interests percentage		50.00%
Milestone payments payable		$ 155,000,000.0
Royalties payment percentage		50.00%
Revenue Interest Purchase Agreement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Royalty financing liability			$ 85,000,000.0
Escrow deposit		$ 5,000,000.0	5,000,000.0					3,500,000			$ 1,500,000
Royalty financing liability transaction cost		5,000,000.0	5,000,000.0					5,000,000.0
Senior credit agreement payment		56,600,000
Deposit and held in segregated account		7,500,000	$ 7,500,000
Royalty and milestone interests proceeds		7,500,000
Royalty and milestone interests remaining proceeds		$ 10,900,000
Oaktree and Sagard | License And Development Agreement With Almairall S.A.
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Percentage of ownership interest		10.00%
Common Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock share price | $ / shares						$ 20.00
Pre-funded Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock share price | $ / shares						0.02
Common Stock and Common Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock share price | $ / shares						15.00
Common Warrants and Pre-funded Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Shares issued price per prefunded warrant | $ / shares						$ 14.98
Proceeds from issuance of common stock and warrants						$ 28,100,000
Warrants expiration term						5 years
Maximum | Common Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares issued and sold | shares						2,000,000
Maximum | Pre-funded Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares issued and sold | shares						233,334
Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Reverse stock split, description	On February 15, 2023, the Company effected a 20:1 reverse stock split of its common stock in order to regain compliance with Nasdaq's continued listing requirements.
Reverse stock split, conversion ratio	0.05
Senior Credit Agreement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Line of credit due								$ 44,700,000	$ 150,000,000.0
Purchase price | $ / shares				$ 252.60
Debt instrument, maximum borrowing capacity					$ 225,000,000.0
Number of tranches | Tranche				2	5
Senior Credit Agreement, maturity date								Jun. 19, 2026
Bearing interest at a fixed annual rate					11.00%
Additional debt amount tranches available					$ 75,000,000.0
Percentage of warrant exercise price uderlying lower				50.00%
Amended the warrants held issued, start date				Jun. 19, 2020
Amended the warrants held issued, end date				Aug. 04, 2020
Mandatory prepayment of principal percentage				62.50%
Fee percentage				7.00%			5.00%
Exit fee percentage				2.00%			2.00%
Prepayment fee percentage				5.00%			3.00%
Amendment fee				$ 300,000
Additional mandatory prepayment in principal				$ 12,500,000
Proceeds from credit agreement								$ 40,000,000.0
Repay to credit agreement								$ 27,400,000
Senior Credit Agreement | Amendment Provides Exercise Price for 50% of Shares Underlying
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares				$ 22.00
Senior Credit Agreement | Common Stock
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares					$ 252.60
Senior Credit Agreement | Maximum | Common Stock
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrant to purchase common stock | shares					45,420
Senior Credit Agreement | Tranche A
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn					$ 100,000,000.0
Senior Credit Agreement | Tranche B
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn					25,000,000.0
Senior Credit Agreement | Tranche C
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn					$ 25,000,000.0
Senior Credit Agreement | Subsequent Event | Oaktree
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Accounts payable owed to counterparties										$ 10,000,000.0
Senior Credit Agreement Sixth Amendments [Member]
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Line of credit due						$ 7,500,000
Fee percentage						5.00%
Exit fee percentage						2.00%
Prepayment fee percentage						3.00%
Additional prepayment in principal						$ 6,900,000
Senior Credit Agreement Fourth Amendment
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares				10.00
Senior Credit Agreement Fourth Amendment | Oaktree
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Line of credit due							$ 7,500,000
Senior Credit Agreement Fifth Amendment
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Additional prepayment in principal							10,000,000.0
Senior Credit Agreement Third Amendment
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Repay to credit agreement							$ 13,700,000
Senior Credit Agreement Third Amendment | Amendment Provides Exercise Price for 50% of Shares Underlying
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares				$ 22.00
ATM Shares | Sales Agreement | SVB Leerink LLC
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock share price | $ / shares								$ 7.40	$ 29.80
Number of shares issued and sold | shares								1,263,251	38,142
Common stock value												$ 100,000,000
Common stock, par value (in dollars per share) | $ / shares												$ 0.001
Underwritten Public Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares issued and sold | shares						1,766,667