Company and Nature of Business - Additional Information (Detail)			12 Months Ended
	Jan. 19, 2022 USD ($) Tranche $ / shares	Jun. 19, 2020 USD ($) Tranche $ / shares shares	Dec. 31, 2021 USD ($) Segment $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 shares	Aug. 20, 2021 USD ($) $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of operating segments | Segment			3
Substantial doubt about going concern, conditions or events			The Company projects insufficient liquidity to fund its operations through the next twelve months beyond the date of the issuance of these consolidated financial statements. This condition raises substantial doubt about the Company’s ability to continue as a going concern. Additionally, the Company has financial covenants associated with its Senior Credit Agreement with Oaktree that are measured each quarter. The Company is in compliance with such financial covenants as of December 31, 2021. However, the Company is forecasting that it will be in violation of both the minimum liquidity and revenue covenant included within the Senior Credit Agreement during the twelve month period subsequent to the date of this filing. Pursuant to ASC 205-40-50, the Company’s forecast does not reflect management’s plans that are outside of the Company’s control as described below. Violation of any covenant under the Credit Agreement provides the lenders with the option to accelerate the maturity of the Credit Facility, which carried an outstanding balance of $150.0 million as of December 31, 2021. Should the lenders accelerate the maturity of the Credit Facility, the Company would not have sufficient cash on hand or available liquidity to repay the outstanding debt in the event of default. These conditions and events raise substantial doubt about the Company’s ability to continue as a going concern.
Substantial doubt about going concern, within next twelve month			true
Loss on extinguishment of debt				$ 10,278,000
Accumulated deficit			$ 913,412,000	713,644,000
Cash and cash equivalents			35,202,000	69,587,000
Restricted Cash			16,500,000
Short-term investments			10,207,000	138,636,000
Common stock value			$ 111,000	$ 95,000
Common stock, par value (in dollars per share) | $ / shares			$ 0.001	$ 0.001
Common Stock
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares issued and sold | shares				11,607,322	14,006,575
Senior Credit Agreement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Line of credit due			$ 150,000,000.0
Senior Credit Agreement, maximum borrowing capacity		$ 225,000,000.0
Number of tranches | Tranche		5
Senior Credit Agreement, maturity date			Jun. 19, 2026
Loss on extinguishment of debt		$ 7,200,000
Bearing interest at a fixed annual rate		11.00%
Additional debt amount tranches available		$ 75,000,000.0
Number of last tranches | Tranche		5
Proceeds from credit agreement			$ 40,000,000.0
Repay to credit agreement			$ 27,400,000
Senior Credit Agreement | Common Stock
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares		$ 12.63
Senior Credit Agreement | Common Stock | Maximum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrant to purchase common stock | shares		908,393
Senior Credit Agreement | Tranche A
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn		$ 100,000,000.0
Senior Credit Agreement | Tranche B
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn		25,000,000.0
Senior Credit Agreement | Tranche C
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Debt instrument, amount drawn		$ 25,000,000.0
Senior Credit Agreement | Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares	$ 12.63
Number of tranches | Tranche	2
Percentage of warrant exercise price uderlying lower	50.00%
Amended the warrants held issued, start date	Jun. 19, 2020
Amended the warrants held issued, end date	Aug. 04, 2020
Mandatory prepayment of principal percentage	62.50%
Fee percentage	7.00%
Exit fee percentage	2.00%
Prepayment fee percentage	5.00%
Amendment fee	$ 300,000
Additional mandatory prepayment in principal	$ 12,500,000
Number of last tranches | Tranche	2
Senior Credit Agreement | Subsequent Event | Amendment Provides Exercise Price for 50% of Shares Underlying
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Purchase price | $ / shares	$ 1.10
ATM Shares | Sales Agreement | SVB Leerink LLC
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock share price | $ / shares			$ 1.49
Number of shares issued and sold | shares			762,825
Common stock value						$ 100,000,000
Common stock, par value (in dollars per share) | $ / shares						$ 0.001