<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2017-06-19</periodOfReport>

    <dateOfOriginalSubmission>2017-06-21</dateOfOriginalSubmission>

    <issuer>
        <issuerCik>0001300699</issuerCik>
        <issuerName>Athenex, Inc.</issuerName>
        <issuerTradingSymbol>ATNX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001290865</rptOwnerCik>
            <rptOwnerName>Zhang Song-Yi</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ATHENEX, INC.,</rptOwnerStreet1>
            <rptOwnerStreet2>1001 MAIN STREET, SUITE 600</rptOwnerStreet2>
            <rptOwnerCity>BUFFALO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>14203</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001709068</rptOwnerCik>
            <rptOwnerName>Mandra Medical Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>NEWHAVEN TRUSTEES (BVI) LTD., 3RD FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2>J&amp;C BUILDING, P.O. BOX 933, ROAD TOWN</rptOwnerStreet2>
            <rptOwnerCity>TORTOLA</rptOwnerCity>
            <rptOwnerState>D8</rptOwnerState>
            <rptOwnerZipCode>VG1110</rptOwnerZipCode>
            <rptOwnerStateDescription>VIRGIN ISLANDS, BRITISH</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001709077</rptOwnerCik>
            <rptOwnerName>Beansprouts Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>NEWHAVEN TRUSTEES (BVI) LTD., 3RD FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2>J&amp;C BUILDING, P.O. BOX 933, ROAD TOWN</rptOwnerStreet2>
            <rptOwnerCity>TORTOLA</rptOwnerCity>
            <rptOwnerState>D8</rptOwnerState>
            <rptOwnerZipCode>VG1110</rptOwnerZipCode>
            <rptOwnerStateDescription>VIRGIN ISLANDS, BRITISH</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001709117</rptOwnerCik>
            <rptOwnerName>Mui Bing How Tammy</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ATHENEX, INC. 1001 MAIN STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 600</rptOwnerStreet2>
            <rptOwnerCity>BUFFALO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>14203</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2017-06-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>146819</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6802700</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Mandra Medical Limited</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The amount of shares of Common Stock (&quot;Shares&quot;) beneficially owned were inadvertently disclosed as &quot;6,804,700&quot; in the Reporting Person's Form 4 filed June 21, 2017 (&quot;Initial Form 4&quot;).  This amended Form 4 accurately discloses the amount of Shares beneficially owned by the Reporting Persons.  None of the other information disclosed in the Initial Form 4, including its corresponding footnotes are being amended.</footnote>
    </footnotes>

    <remarks>Exhibit List: The Power of Attorneys filed as Exhibits 24.1, 24.2, and 24.3 to the Form 3 filed by the Reporting Person on June 13, 2017 are incorporated herein by reference.</remarks>

    <ownerSignature>
        <signatureName>Song-Yi Zhang, By: /s/ Teresa Bair, attorney-in-fact</signatureName>
        <signatureDate>2017-07-28</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Mui Bing How Tammy, By: /s/ Teresa Bair, attorney-in-fact</signatureName>
        <signatureDate>2017-07-28</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Mandra Medical Limited, By: /s/ Song-Yi Zhang, Director, By: /s/ Teresa Bair, attorney-in-fact</signatureName>
        <signatureDate>2017-07-28</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Beansprouts Limited, By: /s/ Song-Yi Zhang, Director, By: /s/ Teresa Bair, attorney-in-fact</signatureName>
        <signatureDate>2017-07-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
