Chief Compliance Officer

0001104659-23-018131.txt : 20230210 0001104659-23-018131.hdr.sgml : 20230210 20230210110249 ACCESSION NUMBER: 0001104659-23-018131 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20221231 FILED AS OF DATE: 20230210 DATE AS OF CHANGE: 20230210 EFFECTIVENESS DATE: 20230210 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 23609386 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001300336 XXXXXXXX 12-31-2022 12-31-2022 false Tekla Capital Management LLC

100 Federal Street 19th Floor Boston MA 02110

13F HOLDINGS REPORT 028-10950 000119626 801-61018 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 02-10-2023 0 172 2647841985 INFORMATION TABLE 2 infotable.xml 1Life Healthcare, Inc. Common 68269G107 522455 31266 SH SOLE 522455 0 0 Abbott Laboratories Common 002824100 76090069 693051 SH SOLE 76090069 0 0 AbbVie Inc. Common 00287Y109 77304851 478342 SH SOLE 77304851 0 0 Acadia Healthcare Company, Inc. Common 00404A109 11622678 141189 SH SOLE 11622678 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 1149822 72225 SH SOLE 1149822 0 0 Adaptive Biotechnologies Corp. Common 00650F109 3226227 422281 SH SOLE 3226227 0 0 Addus HomeCare Corp. Common 006739106 4216386 42380 SH SOLE 4216386 0 0 Adicet Bio, Inc. Common 007002108 360541 40329 SH SOLE 360541 0 0 Affimed N.V. Common N01045108 726687 586038 SH SOLE 726687 0 0 Agilent Technologies, Inc. Common 00846U101 6463533 43191 SH SOLE 6463533 0 0 AlerisLife Inc. Common 33832D205 13330 24237 SH SOLE 13330 0 0 Align Technology, Inc. Common 016255101 10718782 50824 SH SOLE 10718782 0 0 Alkermes plc Shares G01767105 8090188 309613 SH SOLE 8090188 0 0 Allscripts Healthcare Solutions, Inc. Common 01988P108 7560151 428580 SH SOLE 7560151 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 34034807 143214 SH SOLE 34034807 0 0 ALX Oncology Holdings Inc. Common 00166B105 746198 66211 SH SOLE 746198 0 0 Amerisourcebergen Corp. Common 03073E105 3383301 20417 SH SOLE 3383301 0 0 Amgen Inc. Common 031162100 133598665 508676 SH SOLE 133598665 0 0 Apellis Pharmaceuticals, Inc. Common 03753U106 3434888 66426 SH SOLE 3434888 0 0 ARCA biopharma, Inc. Common 00211Y506 76608 32461 SH SOLE 76608 0 0 Arcutis Biotherapeutics, Inc. Common 03969K108 2203335 148874 SH SOLE 2203335 0 0 Ardelyx, Inc. Common 039697107 1537313 539408 SH SOLE 1537313 0 0 argenx SE Sponsored ADR 04016X101 31829675 84021 SH SOLE 31829675 0 0 Arrowhead Pharmaceuticals, Inc. Common 04280A100 4073116 100422 SH SOLE 4073116 0 0 Arvinas, Inc. Common 04335A105 1470962 42998 SH SOLE 1470962 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 15118595 123791 SH SOLE 15118595 0 0 Assertio Holdings, Inc. Common 04546C205 1765473 410575 SH SOLE 1765473 0 0 AstraZeneca PLC Sponsored ADR 046353108 69308889 1022255 SH SOLE 69308889 0 0 Avantor, Inc. Common 05352A100 9690602 459488 SH SOLE 9690602 0 0 Beam Therapeutics Inc. Common 07373V105 618603 15817 SH SOLE 618603 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 4608183 20952 SH SOLE 4608183 0 0 Bellicum Pharmaceuticals, Inc. Common 079481404 4320 6000 SH SOLE 4320 0 0 Bicycle Therapeutics PLC Sponsored ADS 088786108 2624810 88676 SH SOLE 2624810 0 0 BioCryst Pharmaceuticals, Inc. Common 09058V103 7722653 672705 SH SOLE 7722653 0 0 Biogen Inc. Common 09062X103 54118476 195430 SH SOLE 54118476 0 0 Biohaven Ltd. Common G1110E107 487008 35087 SH SOLE 487008 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 23884457 230790 SH SOLE 23884457 0 0 BioNTech SE Sponsored ADS 09075V102 15601549 103858 SH SOLE 15601549 0 0 Black Diamond Therapeutics, Inc. Common 09203E105 237582 131990 SH SOLE 237582 0 0 Blueprint Medicines Corp. Common 09627Y109 2966375 67710 SH SOLE 2966375 0 0 Boston Scientific Corp. Common 101137107 35027084 757015 SH SOLE 35027084 0 0 Bristol-Myers Squibb Company Common 110122108 49467712 687529 SH SOLE 49467712 0 0 Cardiovascular Systems, Inc. Common 141619106 2381580 174859 SH SOLE 2381580 0 0 Caribou Biosciences, Inc. Common 142038108 3561683 567147 SH SOLE 3561683 0 0 Catalent, Inc. Common 148806102 5668874 125947 SH SOLE 5668874 0 0 Cerevel Therapeutics Holdings, Inc. Common 15678U128 5566274 176483 SH SOLE 5566274 0 0 Charles River Laboratories International, Inc. Common 159864107 15835883 72675 SH SOLE 15835883 0 0 Cigna Corp. Common 125523100 60512956 182631 SH SOLE 60512956 0 0 Codexis Inc Common 192005106 322123 69125 SH SOLE 322123 0 0 Community Health Systems, Inc. Common 203668108 381607 88335 SH SOLE 381607 0 0 Community Healthcare Trust Inc. Common 20369C106 533420 14900 SH SOLE 533420 0 0 Corbus Pharmaceuticals Holdings, Inc. Common 21833P103 17051 154310 SH SOLE 17051 0 0 Crinetics Pharmaceuticals, Inc. Common 22663K107 839256 45861 SH SOLE 839256 0 0 CRISPR Therapeutics AG Namen AKT H17182108 2239002 55080 SH SOLE 2239002 0 0 CVS Health Corp. Common 126650100 8724541 93621 SH SOLE 8724541 0 0 Cytokinetics, Inc. Common 23282W605 3442869 75139 SH SOLE 3442869 0 0 Danaher Corp. Common 235851102 28052240 105690 SH SOLE 28052240 0 0 Denali Therapeutics, Inc. Common 24823R105 7578781 272520 SH SOLE 7578781 0 0 Dexcom, Inc. Common 252131107 24688019 218015 SH SOLE 24688019 0 0 Diversified Healthcare Trust Common 25525P107 231373 357720 SH SOLE 231373 0 0 Edgewise Therapeutics, Inc. Common 28036F105 1743524 195025 SH SOLE 1743524 0 0 Edwards Lifesciences Corp. Common 28176E108 12787259 171388 SH SOLE 12787259 0 0 Elevance Health, Inc. Common 036752103 7511933 14644 SH SOLE 7511933 0 0 Eli Lilly and Company Common 532457108 105697395 288917 SH SOLE 105697395 0 0 Fulcrum Therapeutics, Inc. Common 359616109 426149 58537 SH SOLE 426149 0 0 Fusion Pharmaceuticals Inc. Common 36118A100 136691 43394 SH SOLE 136691 0 0 G1 Therapeutics, Inc. Common 3621LQ109 2301609 423869 SH SOLE 2301609 0 0 Galera Therapeutics, Inc. Common 36338D108 1338577 898374 SH SOLE 1338577 0 0 Gilead Sciences, Inc. Common 375558103 129671274 1510440 SH SOLE 129671274 0 0 Global Medical REIT Inc. Common 37954A204 1658024 174897 SH SOLE 1658024 0 0 GSK plc ADR Sponsored ADR 37733W204 1470679 41852 SH SOLE 1470679 0 0 Guardant Health, Inc. Common 40131M109 12843405 472184 SH SOLE 12843405 0 0 Harpoon Therapeutics, Inc. Common 41358P106 188617 259910 SH SOLE 188617 0 0 HCA Healthcare, Inc. Common 40412C101 25196520 105003 SH SOLE 25196520 0 0 Healthcare Realty Trust Inc. Common 42226K105 3366199 174686 SH SOLE 3366199 0 0 HealthEquity, Inc. Common 42226A107 6793591 110214 SH SOLE 6793591 0 0 Healthpeak Properties, Inc. Common 42250P103 3770327 150392 SH SOLE 3770327 0 0 Horizon Therapeutics plc Common G46188101 47233031 415053 SH SOLE 47233031 0 0 Humana Inc. Common 444859102 39803821 77713 SH SOLE 39803821 0 0 I-Mab Sponsored ADS 44975P103 679584 162580 SH SOLE 679584 0 0 Icon plc Shares G4705A100 1813130 9334 SH SOLE 1813130 0 0 IDEAYA Biosciences, Inc. Common 45166A102 2419971 133185 SH SOLE 2419971 0 0 IDEXX Laboratories, Inc. Common 45168D104 27767797 68065 SH SOLE 27767797 0 0 Illumina, Inc. Common 452327109 64695508 319958 SH SOLE 64695508 0 0 Intellia Therapeutics, Inc. Common 45826J105 5382445 154269 SH SOLE 5382445 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 644069 52067 SH SOLE 644069 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 9121873 172371 SH SOLE 9121873 0 0 Intuitive Surgical, Inc. Common 46120E602 29899638 112680 SH SOLE 29899638 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 3317717 87840 SH SOLE 3317717 0 0 IQVIA Holdings Inc. Common 46266C105 12932042 63117 SH SOLE 12932042 0 0 Ishares Biothechnology ETF Common 464287556 3225664 24569 SH SOLE 3225664 0 0 Jazz Pharmaceuticals plc Shares G50871105 29119000 182782 SH SOLE 29119000 0 0 Johnson & Johnson Common 478160104 112999295 639679 SH SOLE 112999295 0 0 Karuna Therapeutics, Inc. Common 48576A100 10503318 53452 SH SOLE 10503318 0 0 Koninklijke Philips N.V. NY Reg Shares 500472303 1646801 109860 SH SOLE 1646801 0 0 Kura Oncology, Inc. Common 50127T109 3515517 283281 SH SOLE 3515517 0 0 Laboratory Corporation of America Holdings Common 50540R409 10394558 44142 SH SOLE 10394558 0 0 Lantheus Holdings, Inc. Common 516544103 17472757 342872 SH SOLE 17472757 0 0 LTC Properties, Inc. Common 502175102 6476870 182293 SH SOLE 6476870 0 0 Mallinckrodt plc Shares G5890A102 271622 35048 SH SOLE 271622 0 0 McKesson Corp. Common 58155Q103 24928600 66455 SH SOLE 24928600 0 0 Medical Properties Trust, Inc. Common 58463J304 4586817 411743 SH SOLE 4586817 0 0 Medpace Holdings, Inc. Common 58506Q109 2004088 9435 SH SOLE 2004088 0 0 Medtronic plc Shares G5960L103 25350088 326172 SH SOLE 25350088 0 0 Merck & Co., Inc. Common 58933Y105 61257936 552122 SH SOLE 61257936 0 0 Mereo BioPharma Group plc ADS 589492107 1163312 1551082 SH SOLE 1163312 0 0 Merus N.V. Common N5749R100 1428268 92325 SH SOLE 1428268 0 0 Mirati Therapeutics, Inc. Common 60468T105 2967352 65490 SH SOLE 2967352 0 0 Moderna, Inc. Common 60770K107 47586188 264927 SH SOLE 47586188 0 0 Molina Healthcare, Inc. Common 60855R100 24309145 73615 SH SOLE 24309145 0 0 MoonLake Immunotherapeutics AG Common 61559X104 3150000 300000 SH SOLE 3150000 0 0 Morphic Holding, Inc. Common 61775R105 1193719 44625 SH SOLE 1193719 0 0 MorphoSys AG Sponsored ADS 617760202 293084 81867 SH SOLE 293084 0 0 Natera, Inc. Common 632307104 1979256 49272 SH SOLE 1979256 0 0 National Health Investors, Inc. Common 63633D104 524184 10038 SH SOLE 524184 0 0 Neurocrine Biosciences, Inc. Common 64125C109 13485732 112908 SH SOLE 13485732 0 0 NexGel, Inc. Common 65344E107 5304 4243 SH SOLE 5304 0 0 Nkarta, Inc. Common 65487U108 173638 28988 SH SOLE 173638 0 0 Novartis AG Sponsored ADR 66987V109 12358332 136225 SH SOLE 12358332 0 0 Novavax, Inc. Common 670002401 655864 63800 SH SOLE 655864 0 0 Novo Nordisk A/S Sponsored ADR 670100205 17664983 130523 SH SOLE 17664983 0 0 Omega Healthcare Investors, Inc. Common 681936100 8564802 306433 SH SOLE 8564802 0 0 Option Care Health, Inc. Common 68404L201 1955098 64975 SH SOLE 1955098 0 0 Perrigo Company plc Shares G97822103 1746226 51224 SH SOLE 1746226 0 0 Pfizer Inc. Common 717081103 74665391 1457170 SH SOLE 74665391 0 0 Physicians Realty Trust Common 71943U104 2441682 168741 SH SOLE 2441682 0 0 Pliant Therapeutics, Inc. Common 729139105 681054 35233 SH SOLE 681054 0 0 Praxis Precision Medicines, Inc. Common 74006W108 178500 75000 SH SOLE 178500 0 0 Precision BioSciences, Inc. Common 74019P108 267195 224534 SH SOLE 267195 0 0 Prometheus Biosciences, Inc. Common 74349U108 4206070 38237 SH SOLE 4206070 0 0 Protagonist Therapeutics, Inc. Common 74366E102 1333977 122271 SH SOLE 1333977 0 0 Pyxis Oncology, Inc. Common 747324101 949126 708303 SH SOLE 949126 0 0 R1 RCM Inc. Common 77634L105 2215743 202351 SH SOLE 2215743 0 0 Rallybio Corporation Common 75120L100 11346830 1727067 SH SOLE 11346830 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 87200724 120862 SH SOLE 87200724 0 0 Repare Therapeutics Inc. Common 760273102 428797 29150 SH SOLE 428797 0 0 ResMed Inc. Common 761152107 12633283 60699 SH SOLE 12633283 0 0 Sabra Health Care REIT, Inc. Common 78573L106 6347504 510660 SH SOLE 6347504 0 0 Sanofi Sponsored ADR 80105N105 5978877 123454 SH SOLE 5978877 0 0 Sarepta Therapeutics, Inc. Common 803607100 18265467 140959 SH SOLE 18265467 0 0 Scholar Rock Holding Corp. Common 80706P103 984939 108833 SH SOLE 984939 0 0 Seagen Inc. Common 81181C104 14420621 112214 SH SOLE 14420621 0 0 Smith & Nephew plc Sponsored ADR 83175M205 4886182 181710 SH SOLE 4886182 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 12257191 147677 SH SOLE 12257191 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 42256 114670 SH SOLE 42256 0 0 STERIS plc Shares G8473T100 3078598 16669 SH SOLE 3078598 0 0 Stevanato Group Societa' Per Azioni Ordinary Shares T9224W109 1279284 71190 SH SOLE 1279284 0 0 Stryker Corp. Common 863667101 40127655 164128 SH SOLE 40127655 0 0 Sutro Biopharma, Inc. Common 869367102 1192050 147531 SH SOLE 1192050 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 2995898 117717 SH SOLE 2995898 0 0 Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205 1639139 105073 SH SOLE 1639139 0 0 Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 4192017 459651 SH SOLE 4192017 0 0 Thermo Fisher Scientific Inc. Common 883556102 51602406 93705 SH SOLE 51602406 0 0 Theseus Pharmaceuticals, Inc. Common 88369M101 498000 100000 SH SOLE 498000 0 0 Travere Therapeutics, Inc. Common 89422G107 8801476 418520 SH SOLE 8801476 0 0 TScan Therapeutics, Inc. Common 89854M101 326000 200000 SH SOLE 326000 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 3107121 67065 SH SOLE 3107121 0 0 uniQure N.V. Shares N90064101 14790951 652446 SH SOLE 14790951 0 0 United Therapeutics Corp. Common 91307C102 32001763 115077 SH SOLE 32001763 0 0 Unitedhealth Group Inc. Common 91324P102 143438078 270546 SH SOLE 143438078 0 0 Universal Health Realty Income Trust Common 91359E105 537344 11258 SH SOLE 537344 0 0 Vaxcyte, Inc. Common 92243G108 239750 5000 SH SOLE 239750 0 0 VectivBio Holding AG Common H9060V101 6351631 737704 SH SOLE 6351631 0 0 Ventas, Inc. Common 92276F100 3003979 66681 SH SOLE 3003979 0 0 Vertex Pharmaceuticals Inc. Common 92532F100 95396452 330343 SH SOLE 95396452 0 0 VYNE Therapeutics Inc. Common 92941V209 20309 135395 SH SOLE 20309 0 0 Welltower Inc. Common 95040Q104 2719276 41484 SH SOLE 2719276 0 0 Xencor, Inc. Common 98401F105 5216541 200328 SH SOLE 5216541 0 0 Xenon Pharmaceuticals Inc. Common 98420N105 3300843 83714 SH SOLE 3300843 0 0 Zai Lab Ltd. ADR 98887Q104 1329310 43300 SH SOLE 1329310 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 33005670 258868 SH SOLE 33005670 0 0 Zoetis Inc. Class A 98978V103 20064747 136914 SH SOLE 20064747 0 0