The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
1Life Healthcare, Inc.Common68269G10763331,266SH SOLE 31,26600
Abbott LaboratoriesCommon00282410077,616657,038SH SOLE 657,03800
AbbVie Inc.Common00287Y10956,547524,213SH SOLE 524,21300
Adaptive Biotechnologies Corp.Common00650F10911,479337,722SH SOLE 337,72200
Addus HomeCare Corp.Common0067391066,67083,632SH SOLE 83,63200
Affimed N.V.CommonN010451083,622586,038SH SOLE 586,03800
Agilent Technologies, Inc.Common00846U1016,24239,625SH SOLE 39,62500
Align Technology, Inc.Common0162551014,9637,459SH SOLE 7,45900
Alkermes plcSharesG0176710511,529373,824SH SOLE 373,82400
Alnylam Pharmaceuticals, Inc.Common02043Q10735,816189,695SH SOLE 189,69500
ALX Oncology Holdings Inc.Common00166B1055247,099SH SOLE 7,09900
Amgen Inc.Common031162100122,256574,918SH SOLE 574,91800
Amicus Therapeutics, Inc.Common03152W1095,608587,277SH SOLE 587,27700
Anthem, Inc.Common0367521035,45914,644SH SOLE 14,64400
Apellis Pharmaceuticals, Inc.Common03753U1066,454195,820SH SOLE 195,82000
ARCA biopharma, Inc.Common00211Y5069632,461SH SOLE 32,46100
Arcutis Biotherapeutics, Inc.Common03969K1083,145131,633SH SOLE 131,63300
Ardelyx, Inc.Common039697107712539,408SH SOLE 539,40800
Arena Pharmaceuticals, Inc.Common0400476074,98083,629SH SOLE 83,62900
argenx SESponsored ADR04016X10111,61438,456SH SOLE 38,45600
Arrowhead Pharmaceuticals, Inc.Common04280A10012,749204,214SH SOLE 204,21400
Arvinas, Inc.Common04335A1057,06785,997SH SOLE 85,99700
Ascendis Pharma A/SSponsored ADR04351P10110,80667,794SH SOLE 67,79400
Assertio Holdings, Inc.Common04546C205372410,575SH SOLE 410,57500
AstraZeneca plcSponsored ADR04635310848,824812,927SH SOLE 812,92700
Atreca, Inc.Class A Common04965G1091,429229,372SH SOLE 229,37200
Aurinia Pharmaceuticals Inc.Common05156V1025,595252,821SH SOLE 252,82100
Becton, Dickinson and CompanyCommon07588710910,64643,307SH SOLE 43,30700
BeiGene, Ltd.Sponsored ADR07725L10223,14963,772SH SOLE 63,77200
Bellicum Pharmaceuticals, Inc.Common079481404186,000SH SOLE 6,00000
Bio-Techne Corp.Common09073M1042,6175,400SH SOLE 5,40000
Biogen Inc.Common09062X10366,178233,853SH SOLE 233,85300
Biohaven Pharmaceutical Holding Company Ltd.CommonG1119610512,61390,799SH SOLE 90,79900
BioMarin Pharmaceutical Inc.Common09061G1019,893128,004SH SOLE 128,00400
BioNTech SESponsored ADS09075V10222,04680,757SH SOLE 80,75700
Black Diamond Therapeutics, Inc.Common09203E1051,117131,990SH SOLE 131,99000
Bolt Biotherapeutics, Inc.Common09770210482365,025SH SOLE 65,02500
Boston Scientific Corp.Common1011371078,068185,931SH SOLE 185,93100
Bristol-Myers Squibb CompanyCommon11012210836,226612,236SH SOLE 612,23600
Caribou Biosciences, Inc.Common14203810815,621699,377SH SOLE 699,37700
Catalent, Inc.Common14880610219,151143,913SH SOLE 143,91300
Charles River Laboratories International, Inc.Common15986410732,38878,484SH SOLE 78,48400
ChemoCentryx, Inc.Common16383L1061,33778,197SH SOLE 78,19700
Cigna Corp.Common12552310044,383221,740SH SOLE 221,74000
Codexis, Inc.Common1920051061,87180,448SH SOLE 80,44800
Community Health Systems, Inc.Common2036681081,188101,535SH SOLE 101,53500
Community Healthcare Trust Inc.Common20369C10667314,900SH SOLE 14,90000
Corbus Pharmaceuticals Holdings, Inc.Common21833P103422413,481SH SOLE 413,48100
CRISPR Therapeutics AGNamen AKTH1718210818,170162,337SH SOLE 162,33700
CVS Health Corp.Common12665010012,513147,453SH SOLE 147,45300
Danaher Corp.Common23585110245,265148,683SH SOLE 148,68300
Denali Therapeutics Inc.Common24823R10511,221222,420SH SOLE 222,42000
DENTSPLY SIRONA Inc.Common24906P10921,335367,521SH SOLE 367,52100
Dexcom, Inc.Common25213110723,50442,980SH SOLE 42,98000
Diversified Healthcare TrustCommon25525P1071,213357,720SH SOLE 357,72000
Edwards Lifesciences Corp.Common28176E10822,034194,630SH SOLE 194,63000
Eli Lilly and CompanyCommon53245710863,639275,432SH SOLE 275,43200
Endo International plcSharesG304011061,603494,607SH SOLE 494,60700
Exact Sciences Corp.Common30063P10521,503225,282SH SOLE 225,28200
Fate Therapeutics, Inc.Common31189P1024,31172,727SH SOLE 72,72700
Five Star Senior Living Inc.Common33832D20510624,237SH SOLE 24,23700
Forma Therapeutics Holdings, Inc.Shares34633R1043,474149,825SH SOLE 149,82500
Fulcrum Therapeutics, Inc.Common3596161091,23843,898SH SOLE 43,89800
Fusion Pharmaceuticals Inc.Common36118A10034443,394SH SOLE 43,39400
G1 Therapeutics, Inc.Common3621LQ1098,379624,369SH SOLE 624,36900
Galera Therapeutics, Inc.Common36338D1087,277898,374SH SOLE 898,37400
Gamida Cell Ltd.SharesM47364100463118,142SH SOLE 118,14200
Gilead Sciences, Inc.Common375558103119,3081,708,065SH SOLE 1,708,06500
Global Medical REIT Inc.Common37954A2042,571174,897SH SOLE 174,89700
Guardant Health, Inc.Common40131M10948,502387,984SH SOLE 387,98400
HCA Healthcare, Inc.Common40412C10127,175111,961SH SOLE 111,96100
Health Care Select Sector SPDR FundSBI Healthcare81369Y20916,909132,830SH SOLE 132,83000
Healthcare Realty Trust Inc.Common4219461043,098104,024SH SOLE 104,02400
Healthcare Trust of America, Inc.Common42225P5012,09670,662SH SOLE 70,66200
Healthpeak Properties, Inc.Common42250P1035,035150,392SH SOLE 150,39200
Helix Acquisition Corp.Class A CommonG4444C1022,468250,000SH SOLE 250,00000
Hologic, Inc.Common4364401012,09228,347SH SOLE 28,34700
Horizon Therapeutics plcSharesG4618810199,719910,340SH SOLE 910,34000
Humana Inc.Common44485910220,67753,135SH SOLE 53,13500
I-MabSponsored ADS44975P10311,785162,580SH SOLE 162,58000
Icon plcSharesG4705A10025,90698,871SH SOLE 98,87100
IDEXX Laboratories, Inc.Common45168D10449,54279,663SH SOLE 79,66300
Illumina, Inc.Common45232710978,673193,963SH SOLE 193,96300
Intellia Therapeutics, Inc.Common45826J1057,80558,180SH SOLE 58,18000
Intercept Pharmaceuticals, Inc.Common45845P10877352,067SH SOLE 52,06700
Intra-Cellular Therapies, Inc.Common46116X10112,094324,401SH SOLE 324,40100
Intuitive Surgical, Inc.Common46120E60219,88520,002SH SOLE 20,00200
Ionis Pharmaceuticals, Inc.Common46222210010,817322,521SH SOLE 322,52100
IQVIA Holdings Inc.Common46266C10518,35976,644SH SOLE 76,64400
iTeos Therapeutics, Inc.Common46565G1041,14442,362SH SOLE 42,36200
Jazz Pharmaceuticals plcSharesG5087110514,852114,059SH SOLE 114,05900
Johnson & JohnsonCommon47816010483,439516,652SH SOLE 516,65200
KalVista Pharmaceuticals, Inc.Common4834971031,745100,000SH SOLE 100,00000
Karuna Therapeutics, Inc.Common48576A10012,289100,458SH SOLE 100,45800
Koninklijke Philips N.V.NY Reg Shares5004723037,323164,790SH SOLE 164,79000
Kura Oncology, Inc.Common50127T1095,122273,463SH SOLE 273,46300
Laboratory Corporation of America HoldingsSponsored ADR50540R40926,64094,656SH SOLE 94,65600
LTC Properties, Inc.Common5021751025,777182,293SH SOLE 182,29300
McKesson Corp.Common58155Q10336,203181,577SH SOLE 181,57700
Medical Properties Trust, Inc.Common58463J3048,264411,743SH SOLE 411,74300
Medpace Holdings, Inc.Common58506Q1093,57218,871SH SOLE 18,87100
Medtronic plcSharesG5960L10375,301600,722SH SOLE 600,72200
Merck & Co., Inc.Common58933Y10561,313816,305SH SOLE 816,30500
Mereo BioPharma Group plcADS5894921073,7541,551,082SH SOLE 1,551,08200
Mettler-Toledo International Inc.Common5926881059,1596,650SH SOLE 6,65000
Mirati Therapeutics, Inc.Common60468T10514,82283,784SH SOLE 83,78400
Moderna, Inc.Common60770K107176,826459,456SH SOLE 459,45600
Molina Healthcare, Inc.Common60855R10022,68883,625SH SOLE 83,62500
Morphic Holding, Inc.Common61775R1051,98435,025SH SOLE 35,02500
MorphoSys AGSponsored ADS61776020296381,867SH SOLE 81,86700
National Health Investors, Inc.Common63633D10453710,038SH SOLE 10,03800
Neurocrine Biosciences, Inc.Common64125C10911,951124,609SH SOLE 124,60900
Nkarta, Inc.Common65487U10880628,988SH SOLE 28,98800
Novartis AGSponsored ADR66987V10911,140136,225SH SOLE 136,22500
Novavax, Inc.Common67000240131,406151,491SH SOLE 151,49100
Novo Nordisk A/SSponsored ADR6701002059,18895,703SH SOLE 95,70300
Omega Healthcare Investors, Inc.Common6819361009,181306,433SH SOLE 306,43300
Organon & Co.Common68622V1061223,717SH SOLE 3,71700
Owens & Minor, Inc.Common6907321029,230294,967SH SOLE 294,96700
PerkinElmer, Inc.Common7140461095,79633,444SH SOLE 33,44400
Perrigo Company plcSharesG978221032,42451,224SH SOLE 51,22400
Pfizer Inc.Common71708110319,371450,379SH SOLE 450,37900
Physicians Realty TrustCommon71943U1048,735495,733SH SOLE 495,73300
Praxis Precision Medicines, Inc.Common74006W1081,38775,000SH SOLE 75,00000
Precision BioSciences, Inc.Common74019P10872763,001SH SOLE 63,00100
Protagonist Therapeutics, Inc.Common74366E1021,52886,237SH SOLE 86,23700
Qiagen N.V.SharesN724821235,574107,855SH SOLE 107,85500
R1 RCM Inc.Common7493971054,454202,351SH SOLE 202,35100
Rallybio Corp.Common75120L10037,6082,308,672SH SOLE 2,308,67200
Regeneron Pharmaceuticals, Inc.Common75886F10789,576148,015SH SOLE 148,01500
ResMed Inc.Common7611521073,74014,189SH SOLE 14,18900
Sabra Health Care REIT, Inc.Common78573L1067,517510,660SH SOLE 510,66000
SanofiSponsored ADR80105N1057,388153,254SH SOLE 153,25400
Sarepta Therapeutics, Inc.Common80360710039,444426,514SH SOLE 426,51400
Scholar Rock Holding Corp.Common80706P1033,594108,833SH SOLE 108,83300
Seagen Inc.Common81181C10435,205207,334SH SOLE 207,33400
Smith & Nephew plcSponsored ADR83175M2056,240181,710SH SOLE 181,71000
Spectrum Pharmaceuticals, Inc.Common84763A108250114,670SH SOLE 114,67000
STERIS plcSharesG8473T1003,40516,669SH SOLE 16,66900
Stevanato Group SpASharesT9224W1093,490137,872SH SOLE 137,87200
Stoke Therapeutics, Inc.Common86150R1072,52599,263SH SOLE 99,26300
Stryker Corp.Common86366710139,690150,500SH SOLE 150,50000
Sutro Biopharma, Inc.Common8693671027,559400,147SH SOLE 400,14700
Syneos Health, Inc.Class A87166B10221,313243,633SH SOLE 243,63300
Takeda Pharmaceutical Company Ltd.Sponsored ADS8740602053,442210,146SH SOLE 210,14600
TCR2 Therapeutics Inc.Common87808K1062,007235,808SH SOLE 235,80800
Teva Pharmaceutical Industries Ltd.Sponsored ADR8816242095,919607,651SH SOLE 607,65100
Theravance Biopharma, Inc.CommonG8807B1064,857656,296SH SOLE 656,29600
Thermo Fisher Scientific Inc.Common88355610283,480146,116SH SOLE 146,11600
Travere Therapeutics, Inc.Common89422G1075,162212,869SH SOLE 212,86900
TScan Therapeutics, Inc.Common89854M1011,668200,000SH SOLE 200,00000
Turning Point Therapeutics, Inc.Common90041T1087,927119,324SH SOLE 119,32400
Ultragenyx Pharmaceutical Inc.Common90400D10812,692140,726SH SOLE 140,72600
uniQure N.V.SharesN900641017,587237,008SH SOLE 237,00800
United Therapeutics Corp.Class B91307C10226,753144,940SH SOLE 144,94000
Unitedhealth Group Inc.Common91324P102119,617306,129SH SOLE 306,12900
Universal Health Realty Income TrustShares91359E10562211,258SH SOLE 11,25800
Universal Health Services, Inc.Class B9139031008,30560,023SH SOLE 60,02300
VectivBio Holding AGSharesH9060V1015,372756,502SH SOLE 756,50200
Ventas, Inc.Common92276F10013,699248,131SH SOLE 248,13100
Verona Pharma plcSponsored ADR9250501064,120751,905SH SOLE 751,90500
Vertex Pharmaceuticals Inc.Common92532F10049,528273,046SH SOLE 273,04600
Vir Biotechnology, Inc.Common92764N1023,54381,400SH SOLE 81,40000
VYNE Therapeutics Inc.Common92941V209188135,395SH SOLE 135,39500
Waters Corp.Common94184810310,16928,461SH SOLE 28,46100
Welltower Inc.Common95040Q10416,734203,083SH SOLE 203,08300
West Pharmaceutical Services, Inc.Common9553061052,6496,240SH SOLE 6,24000
Xenon Pharmaceuticals Inc.Common98420N1052,583169,030SH SOLE 169,03000
Zai Lab Ltd.ADR98887Q1043,95537,523SH SOLE 37,52300
Zimmer Biomet Holdings, Inc.Common98956P10232,595222,703SH SOLE 222,70300
Zoetis Inc.Class A98978V10327,684142,597SH SOLE 142,59700
Zogenix, Inc.Common98978L2041,35288,977SH SOLE 88,97700