The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
1Life Healthcare, Inc.Common68269G1071,22231,266SH SOLE 31,26600
Abbott LaboratoriesCommon00282410089,120743,657SH SOLE 743,65700
AbbVie Inc.Common00287Y10967,070619,759SH SOLE 619,75900
ACADIA Pharmaceuticals Inc.Common0042251088,560331,789SH SOLE 331,78900
Adaptive Biotechnologies Corp.Common00650F10913,597337,722SH SOLE 337,72200
Addus HomeCare Corp.Common0067391063,93737,640SH SOLE 37,64000
Affimed N.V.CommonN010451082,278288,019SH SOLE 288,01900
Agilent Technologies, Inc.Common00846U1016,67852,525SH SOLE 52,52500
Alexion Pharmaceuticals, Inc.Common01535110916,926110,693SH SOLE 110,69300
Align Technology, Inc.Common0162551015,3759,925SH SOLE 9,92500
Alkermes plcSharesG017671053,174169,930SH SOLE 169,93000
Allakos Inc.Common01671P10018,783163,645SH SOLE 163,64500
Alnylam Pharmaceuticals, Inc.Common02043Q10721,871154,902SH SOLE 154,90200
Amedisys, Inc.Common0234361085,13619,395SH SOLE 19,39500
Amgen Inc.Common031162100103,644416,560SH SOLE 416,56000
Amicus Therapeutics, Inc.Common03152W1096,142621,659SH SOLE 621,65900
Anthem, Inc.Common03675210359,147164,777SH SOLE 164,77700
Apellis Pharmaceuticals, Inc.Common03753U1066,545152,538SH SOLE 152,53800
ARCA biopharma, Inc.Common00211Y50611832,461SH SOLE 32,46100
Arcutis Biotherapeutics, Inc.Common03969K1083,808131,633SH SOLE 131,63300
Ardelyx, Inc.Common0396971074,023607,698SH SOLE 607,69800
Arena Pharmaceuticals, Inc.Common04004760713,627196,385SH SOLE 196,38500
Argenx SESponsored ADR04016X10117,72064,344SH SOLE 64,34400
Arrowhead Pharmaceuticals, Inc.Common04280A1008,812132,886SH SOLE 132,88600
Arvinas, Inc.Common04335A1055,68485,997SH SOLE 85,99700
Ascendis Pharma A/SSponsored ADR04351P10115,251118,336SH SOLE 118,33600
Assertio Holdings, Inc.Common04546C1061,1211,642,302SH SOLE 1,642,30200
AstraZeneca PLCSponsored ADR04635310817,120344,333SH SOLE 344,33300
Atreca, Inc.Class A Common04965G1095,403352,424SH SOLE 352,42400
Aurinia Pharmaceuticals Inc.Common05156V1025,167397,920SH SOLE 397,92000
Becton, Dickinson and Co.Common07588710910,53043,307SH SOLE 43,30700
BeiGene, Ltd.Sponsored ADR07725L10214,05940,389SH SOLE 40,38900
Bellicum Pharmaceuticals, Inc.Common079481404236,000SH SOLE 6,00000
Bio-Techne Corp.Common09073M1042,9037,600SH SOLE 7,60000
Biogen Inc.Common09062X10369,055246,844SH SOLE 246,84400
BioMarin Pharmaceutical Inc.Common09061G1019,666128,004SH SOLE 128,00400
BioNTech SESponsored ADS09075V1027,51468,814SH SOLE 68,81400
Black Diamond Therapeutics, Inc.Common09203E1053,202131,990SH SOLE 131,99000
Blueprint Medicines Corp.Common09627Y10911,930122,699SH SOLE 122,69900
Boston Scientific Corp.Common1011371077,186185,931SH SOLE 185,93100
BridgeBio Pharma, Inc.Common10806X1024,60274,714SH SOLE 74,71400
Bristol-Myers Squibb Co.Common11012210856,341892,453SH SOLE 892,45300
Catalent, Inc.Common1488061028,42780,025SH SOLE 80,02500
Celldex Therapeutics, Inc.Common15117B2021457,053SH SOLE 7,05300
CellectisSponsored ADR15117K10324211,955SH SOLE 11,95500
Centene Corp.Common15135B1014,30167,290SH SOLE 67,29000
Charles River Laboratories International, Inc.Common15986410712,48443,074SH SOLE 43,07400
ChemoCentryx, Inc.Common16383L1067,401144,447SH SOLE 144,44700
Cigna Corp.Common12552310045,912189,921SH SOLE 189,92100
Clearside Biomedical, Inc.Common185063104408165,330SH SOLE 165,33000
Cogent Biosciences, Inc.Common19240Q2014,721537,742SH SOLE 537,74200
Community Health Systems, Inc.Common2036681081,589117,535SH SOLE 117,53500
Community Healthcare Trust Inc.Common20369C10668714,900SH SOLE 14,90000
Corbus Pharmaceuticals Holdings, Inc.Common21833P103815413,481SH SOLE 413,48100
CRISPR Therapeutics AGNamen AKTH1718210818,394150,958SH SOLE 150,95800
CVS Health Corp.Common12665010016,550219,995SH SOLE 219,99500
CymaBay Therapeutics, Inc.Common23257D10340088,102SH SOLE 88,10200
Danaher Corp.Common23585110243,044191,240SH SOLE 191,24000
Deciphera Pharmaceuticals, Inc.Common24344T10113,797307,703SH SOLE 307,70300
Denali Therapeutics Inc.Common24823R1058,570150,086SH SOLE 150,08600
DENTSPLY SIRONA Inc.Common24906P10922,425351,427SH SOLE 351,42700
Dexcom, Inc.Common25213110726,82674,643SH SOLE 74,64300
Dicerna Pharmaceuticals, Inc.Common2530311081,74368,150SH SOLE 68,15000
Diversified Healthcare TrustCommon25525P1071,710357,720SH SOLE 357,72000
Editas Medicine, Inc.Common28106W10363815,190SH SOLE 15,19000
Edwards Lifesciences Corp.Common28176E10819,969238,755SH SOLE 238,75500
Eli Lilly and Co.Common53245710854,573292,114SH SOLE 292,11400
Endo International plcSharesG304011063,939531,570SH SOLE 531,57000
Exact Sciences Corp.Common30063P10522,047167,302SH SOLE 167,30200
Exelixis, Inc.Common30161Q10424,8701,100,920SH SOLE 1,100,92000
Fate Therapeutics, Inc.Common31189P10212,396150,343SH SOLE 150,34300
Five Star Senior Living Inc.Common33832D20514824,237SH SOLE 24,23700
Forma Therapeutics Holdings, Inc.Shares34633R1044,198149,825SH SOLE 149,82500
G1 Therapeutics, Inc.Common3621LQ1099,426391,754SH SOLE 391,75400
Galera Therapeutics, Inc.Common36338D1089,1891,041,845SH SOLE 1,041,84500
Gamida Cell Ltd.SharesM47364100956118,142SH SOLE 118,14200
Genmab A/SSponsored ADS3723032062,39773,015SH SOLE 73,01500
Gilead Sciences, Inc.Common375558103117,3621,815,906SH SOLE 1,815,90600
Global Medical REIT Inc.Common37954A2042,293174,897SH SOLE 174,89700
Grifols, S.A.Sponsored ADR39843840881947,373SH SOLE 47,37300
Guardant Health, Inc.Common40131M10924,230158,727SH SOLE 158,72700
HCA Healthcare, Inc.Common40412C10128,797152,897SH SOLE 152,89700
Health Care Select Sector SPDR FundSBI Healthcare81369Y2091,17410,055SH SOLE 10,05500
Healthcare Realty Trust Inc.Common4219461043,154104,024SH SOLE 104,02400
Healthcare Trust of America, Inc.Common42225P5011,94970,662SH SOLE 70,66200
Healthpeak Properties, Inc.Common42250P1034,773150,392SH SOLE 150,39200
Helix Acquisition Corp.Class A CommonG4444C1022,559250,000SH SOLE 250,00000
Heron Therapeutics, Inc.Common4277461022,126131,183SH SOLE 131,18300
Hologic, Inc.Common4364401012,42232,564SH SOLE 32,56400
Horizon Therapeutics plcSharesG4618810174,638810,932SH SOLE 810,93200
Humana Inc.Common44485910215,65537,341SH SOLE 37,34100
I-MabSponsored ADS44975P1038,089166,896SH SOLE 166,89600
Icon plcSharesG4705A1004,63323,592SH SOLE 23,59200
IDEXX Laboratories, Inc.Common45168D10417,03534,814SH SOLE 34,81400
Illumina, Inc.Common45232710994,783246,793SH SOLE 246,79300
Incyte Corp.Common45337C1028,752107,687SH SOLE 107,68700
Insmed Inc.Common4576693073,35198,387SH SOLE 98,38700
Intellia Therapeutics, Inc.Common45826J1054,26853,180SH SOLE 53,18000
Intercept Pharmaceuticals, Inc.Common45845P1081,77977,067SH SOLE 77,06700
Intra-Cellular Therapies, Inc.Common46116X1017,888232,476SH SOLE 232,47600
Intuitive Surgical, Inc.Common46120E60215,73621,296SH SOLE 21,29600
Ionis Pharmaceuticals, Inc.Common4622221009,728216,371SH SOLE 216,37100
Iovance Biotherapeutics, Inc.Common46226010016,482520,595SH SOLE 520,59500
IQVIA Holdings Inc.Common46266C10513,49469,866SH SOLE 69,86600
Jazz Pharmaceuticals plcSharesG5087110511,08867,456SH SOLE 67,45600
Johnson & JohnsonCommon47816010499,409604,864SH SOLE 604,86400
Jounce Therapeutics, Inc.Common4811161013,926382,237SH SOLE 382,23700
KalVista Pharmaceuticals, Inc.Common4834971031,28550,000SH SOLE 50,00000
Karuna Therapeutics, Inc.Common48576A10010,24885,236SH SOLE 85,23600
Koninklijke Philips N.V.NY Reg Sh5004723033,24756,927SH SOLE 56,92700
Kura Oncology, Inc.Common50127T1097,731273,463SH SOLE 273,46300
Laboratory Corp. of America HoldingsSponsored ADR50540R40925,39699,580SH SOLE 99,58000
LTC Properties, Inc.Common5021751027,605182,293SH SOLE 182,29300
Madrigal Pharmaceuticals, Inc.Common5588681051,56013,340SH SOLE 13,34000
McKesson Corp.Common58155Q10324,565125,948SH SOLE 125,94800
Medical Properties Trust, Inc.Common58463J3048,762411,743SH SOLE 411,74300
Medpace Holdings, Inc.Common58506Q1093,09618,871SH SOLE 18,87100
Medtronic plcSharesG5960L10358,145492,214SH SOLE 492,21400
Merck & Co., Inc.Common58933Y10541,760541,703SH SOLE 541,70300
Mereo BioPharma Group plcADS5894921073,361997,290SH SOLE 997,29000
Mettler-Toledo International Inc.Common59268810511,3269,800SH SOLE 9,80000
Mirati Therapeutics, Inc.Common60468T10514,35283,784SH SOLE 83,78400
Moderna, Inc.Common60770K10761,848472,302SH SOLE 472,30200
Molecular Templates, Inc.Common6085501092,517199,420SH SOLE 199,42000
Molina Healthcare, Inc.Common60855R1009,29639,769SH SOLE 39,76900
Morphic Holding, Inc.Common61775R1055,66789,559SH SOLE 89,55900
MorphoSys AGSponsored ADS6177602021,78581,867SH SOLE 81,86700
National Health Investors, Inc.Common63633D10472610,038SH SOLE 10,03800
Nektar TherapeuticsCommon6402681083,609180,438SH SOLE 180,43800
Neurocrine Biosciences, Inc.Common64125C10920,704212,891SH SOLE 212,89100
New Senior Investment Group Inc.Common6486911031,597256,398SH SOLE 256,39800
Nkarta, Inc.Common65487U10895428,988SH SOLE 28,98800
Novartis AGSponsored ADR66987V10911,645136,225SH SOLE 136,22500
Novavax, Inc.Common67000240119,069105,176SH SOLE 105,17600
Novo Nordisk A/SSponsored ADR6701002053,26448,406SH SOLE 48,40600
Omega Healthcare Investors, Inc.Common68193610011,225306,433SH SOLE 306,43300
Ovid Therapeutics Inc.Sponsored ADR6904691011,498372,733SH SOLE 372,73300
Owens & Minor, Inc.Common69073210210,000266,023SH SOLE 266,02300
PerkinElmer, Inc.Common7140461094,75937,094SH SOLE 37,09400
Perrigo Co. plcSharesG978221032,07351,224SH SOLE 51,22400
Personalis, Inc.Common71535D1064,423179,731SH SOLE 179,73100
Pfizer Inc.Common71708110325,552705,259SH SOLE 705,25900
Physicians Realty TrustCommon71943U1048,760495,733SH SOLE 495,73300
Pieris Pharmaceuticals, Inc.Common7207951032,6301,023,348SH SOLE 1,023,34800
PRA Health Sciences, Inc.Common69354M10815,938103,943SH SOLE 103,94300
Praxis Precision Medicines, Inc.Common74006W1082,45775,000SH SOLE 75,00000
Precision BioSciences, Inc.Common74019P10865263,001SH SOLE 63,00100
R1 RCM Inc.Common7493971053,047123,461SH SOLE 123,46100
Reata Pharmaceuticals, Inc.Class A75615P1033,81038,219SH SOLE 38,21900
Regeneron Pharmaceuticals, Inc.Common75886F10772,629153,505SH SOLE 153,50500
REGENXBIO Inc.Common75901B10774021,700SH SOLE 21,70000
Replimune Group, Inc.Common76029N1066,684219,060SH SOLE 219,06000
ResMed Inc.Common76115210725,677132,344SH SOLE 132,34400
Sabra Health Care REIT, Inc.Common78573L1068,865510,660SH SOLE 510,66000
Sage Therapeutics, Inc.Common78667J1088,542114,119SH SOLE 114,11900
SanofiSponsored ADR80105N1054,03481,554SH SOLE 81,55400
Sarepta Therapeutics, Inc.Common8036071009,613128,987SH SOLE 128,98700
Scholar Rock Holding Corp.Common80706P1032,42547,869SH SOLE 47,86900
Seagen Inc.Common81181C10431,312225,490SH SOLE 225,49000
Smith & Nephew plcShares83175M2053,77399,560SH SOLE 99,56000
Spectrum Pharmaceuticals, Inc.Common84763A108374114,670SH SOLE 114,67000
STERIS plcSharesG8473T10024,149126,779SH SOLE 126,77900
Stryker Corp.Common86366710136,983151,830SH SOLE 151,83000
Sutro Biopharma, Inc.Common86936710213,060573,823SH SOLE 573,82300
Syneos Health, Inc.Class A87166B10220,680272,647SH SOLE 272,64700
Takeda Pharmaceutical Co. Ltd.Sponsored ADS8740602053,837210,146SH SOLE 210,14600
TCR2 Therapeutics Inc.Common87808K1065,207235,808SH SOLE 235,80800
Teladoc Health, Inc.Common87918A1055,39129,664SH SOLE 29,66400
Teleflex Inc.Common8793691069142,200SH SOLE 2,20000
Tenet Healthcare Corp.Common88033G4073,13760,336SH SOLE 60,33600
Tetraphase Pharmaceuticals, Inc.Common881CVR013942,965SH SOLE 42,96500
Teva Pharmaceutical Industries Ltd.Sponsored ADR8816242097,623660,551SH SOLE 660,55100
Theravance Biopharma, Inc.CommonG8807B1069,313456,296SH SOLE 456,29600
Thermo Fisher Scientific Inc.Common88355610251,869113,653SH SOLE 113,65300
Travere Therapeutics, Inc.Common89422G1075,315212,869SH SOLE 212,86900
Trillium Therapeutics Inc.Common89620X5065,684529,226SH SOLE 529,22600
Turning Point Therapeutics, Inc.Common90041T10811,287119,324SH SOLE 119,32400
Ultragenyx Pharmaceutical Inc.Common90400D10811,09997,480SH SOLE 97,48000
uniQure N.V.SharesN900641014,211125,003SH SOLE 125,00300
United Therapeutics Corp.Class B91307C10210,62463,513SH SOLE 63,51300
Unitedhealth Group Inc.Common91324P10278,985212,285SH SOLE 212,28500
Universal Health Realty Income TrustShares91359E10576311,258SH SOLE 11,25800
Universal Health Services, Inc.Class B9139031009,51471,323SH SOLE 71,32300
Ventas, Inc.Common92276F10011,100208,108SH SOLE 208,10800
Verona Pharma plcSponsored ADR9250501066,286751,905SH SOLE 751,90500
Vertex Pharmaceuticals Inc.Common92532F10084,943395,288SH SOLE 395,28800
Vir Biotechnology, Inc.Common92764N1024,17381,400SH SOLE 81,40000
VYNE Therapeutics Inc.Common92941V209927135,395SH SOLE 135,39500
Waters Corp.Common94184810329,187102,710SH SOLE 102,71000
Welltower Inc.Common95040Q10414,547203,083SH SOLE 203,08300
Xenon Pharmaceuticals Inc.Common98420N1052,970165,898SH SOLE 165,89800
Y-mAbs Therapeutics, Inc.Common9842411095,982197,820SH SOLE 197,82000
Zai Lab Ltd.ADR98887Q1045,00737,523SH SOLE 37,52300
Zimmer Biomet Holdings, Inc.Common98956P10233,267207,814SH SOLE 207,81400
Zoetis Inc.Class A98978V1038,90156,521SH SOLE 56,52100
Zogenix, Inc.Common98978L2041,73788,977SH SOLE 88,97700