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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 v5CVQkicAJiKfGrxt/O5rg==

<SEC-DOCUMENT>0001209191-07-065726.txt : 20071121
<SEC-HEADER>0001209191-07-065726.hdr.sgml : 20071121
<ACCEPTANCE-DATETIME>20071121154022
ACCESSION NUMBER:		0001209191-07-065726
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071120
FILED AS OF DATE:		20071121
DATE AS OF CHANGE:		20071121

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Trubion Pharmaceuticals, Inc
		CENTRAL INDEX KEY:			0001298521
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2401 14TH AVENUE
		STREET 2:		SUITE 1050
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121
		BUSINESS PHONE:		2068380500

	MAIL ADDRESS:	
		STREET 1:		2401 14TH AVENUE
		STREET 2:		SUITE 1050
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Mann David A
		CENTRAL INDEX KEY:			0001366316

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33054
		FILM NUMBER:		071263309

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(206) 935-6775

	MAIL ADDRESS:	
		STREET 1:		3651 55TH AVE SW
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98116
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>bos35945_bos1dam.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-11-20</periodOfReport>

    <issuer>
        <issuerCik>0001298521</issuerCik>
        <issuerName>Trubion Pharmaceuticals, Inc</issuerName>
        <issuerTradingSymbol>TRBN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001366316</rptOwnerCik>
            <rptOwnerName>Mann David A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2401 4TH AVE.</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1050</rptOwnerStreet2>
            <rptOwnerCity>SEATTLE</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-11-20</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>10.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>8935</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <ownerSignature>
        <signatureName>/s/ David A. Mann</signatureName>
        <signatureDate>2007-11-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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