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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KpdfvcmhcFLD6+6TzLrVyEAHJDnCKwEcBYyccq+KJqD62AFsmBoQukb7awL+luh6
 4SA0XwZJadMLgNSgqW4nlw==

<SEC-DOCUMENT>0001209191-06-055149.txt : 20061018
<SEC-HEADER>0001209191-06-055149.hdr.sgml : 20061018
<ACCEPTANCE-DATETIME>20061018160131
ACCESSION NUMBER:		0001209191-06-055149
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20061017
FILED AS OF DATE:		20061018
DATE AS OF CHANGE:		20061018

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Trubion Pharmaceuticals, Inc
		CENTRAL INDEX KEY:			0001298521
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	BUSINESS ADDRESS:	
		STREET 1:		2401 14TH AVENUE
		STREET 2:		SUITE 1050
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121
		BUSINESS PHONE:		2068380500

	MAIL ADDRESS:	
		STREET 1:		2401 14TH AVENUE
		STREET 2:		SUITE 1050
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CLARK EDWARD A
		CENTRAL INDEX KEY:			0001378531

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33054
		FILM NUMBER:		061150968

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(206) 543-8706

	MAIL ADDRESS:	
		STREET 1:		UNIVERSITY OF WASHINGTON MEDICAL CENTER
		STREET 2:		BOX 357242, I-319
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98195
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>bos24291_bos01eac.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-10-17</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001298521</issuerCik>
        <issuerName>Trubion Pharmaceuticals, Inc</issuerName>
        <issuerTradingSymbol>TRBN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001378531</rptOwnerCik>
            <rptOwnerName>CLARK EDWARD A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>UNIVERSITY OF WASHINGTON</rptOwnerStreet1>
            <rptOwnerStreet2>BOX 357242, I-319</rptOwnerStreet2>
            <rptOwnerCity>SEATTLE</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98195</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>203317</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <ownerSignature>
        <signatureName>/s/ Lauree Seko</signatureName>
        <signatureDate>2006-10-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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