144 0001298079 XXXXXXXX LIVE 0001479419 KALA BIO, Inc. 001-38150 1167 Massachusetts Avenue Arlington, MA 02476 (781) 996-5252 R K BRAZZELL Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

46748 38963.76 7021040 10/22/2025 NASDAQ Common 10/26/2021 Performance Shares Issuer N 1104 10/26/2021 Not Applicable Common 06/25/2021 Restricted Stock Issuer N 40894 06/25/2021 Not Applicable Common 04/09/2020 Exercised Shares Issuer N 1355 04/09/2020 Cash Common 06/30/2021 Employee Stock Purchase Plan Issuer N 1220 06/30/2021 Cash Common 08/11/2017 Exercised Shares Issuer N 2175 08/11/2017 Cash Y The securities to be sold were acquired upon the purchase of Employee Stock Purchase Plan shares during the period of 6/30/2021 through 6/30/2023. The securities to be sold were acquired upon the vesting of performance shares during the period of 10/26/2021 through 10/26/2022. The securities to be sold were acquired upon the vesting of restricted stock during the period of 6/25/2021 through 6/22/2025. 10/22/2025 /s/ Romulus K Brazzell