Exhibit 99.1

Joint Filing Agreement

In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree to the joint filing with each other on behalf of each of them of such a statement on Schedule 13D (including amendments thereto) with respect to the Common Stock beneficially owned by each of them of Novus Therapeutics, Inc. This Joint Filing Agreement shall be included as an Exhibit to such Schedule 13D.

IN WITNESS WHEREOF, the undersigned hereby execute this Joint Filing Agreement as of the 17^th day of April, 2018.

NOVARTIS BIOVENTURES LTD.
By:	/s/ Bart Dzikowski
Name:	Bart Dzikowski
Title:	Secretary of the Board
By:	/s/ Beat Steffen
Name:	Beat Steffen
Title:	Authorized Signatory
NOVARTIS AG
By:	/s/ Bart Dzikowski
Name:	Bart Dzikowski
Title:	Authorized Signatory
By:	/s/ Campbell Murray
Name:	Campbell Murray
Title:	Authorized Signatory