X0306 4 2016-12-07 0 0001396814 Pacira Pharmaceuticals, Inc. PCRX 0001296965 Williams Kristen Marie C/O PACIRA PHARMACEUTICALS, INC. 5 SYLVAN WAY, SUITE 300 PARSIPPANY NJ 07054 0 1 0 0 CAO and General Counsel Stock Option (Right to Buy) 32.35 2016-12-07 4 A 0 20000 0.00 A 2026-12-07 Common Stock 20000 20000 D The stock option vests and becomes exercisable as to 25% of the option shares on the first anniversary of the grant date, and vests as to the remaining shares in successive equal quarterly installments over the subsequent three years, provided that the reporting person remains in continuous service with the issuer as of each vesting date. /s/ Kristen Williams 2016-12-09