X0306 4 2015-11-11 0 0001130591 XENOPORT INC XNPT 0001296771 Freund John Gordon C/O XENOPORT, INC. 3410 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 0 0 0 Common Stock 2015-11-11 4 S 0 909 6.6822 D 488560 I Through Fund Common Stock 13899 D Common Stock 3080 I Beneficial Ownership Common Stock 22633 I Beneficial Ownership Common Stock 3645 I Beneficial Ownership Common Stock 21200 I Beneficial Ownership Common Stock 27 I Beneficial Ownership Represents 22 shares sold from fund Skyline Venture Partners III, LP and 887 shares sold from fund Skyline Venture Partners Qualified Purchaser Fund III, LP. This total of 909 shares were sold at a range of $6.68 to $6.6825. This will bring the respective funds shares of XenoPort, Inc. down to zero. These shares are held by multiple entities. 227 shares are held by Skyline Venture Management III, L.L.C. and 488,333 shares are held by Skyline Venture Partners V, L.P. John G. Freund is connected to each of these entities as managing director or managing member either directly or through indirect ownership and in such capacity may be deemed to have voting and investment power with respect to shares held by each of these entities. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therin. The shares are held by John G. Freund as custodian for his two sons. The shares are owned by a retirement account of which John G. Freund is the beneficiary. The shares are held by the Paul Brooke 1989 Insurance Trust of which John G. Freund is a trustee. The shares are owned by a revocable trust of which John G. Freund is a trustee. The shares are held by John G. Freund Family Partnership IV, L.P. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therin. /s/ Stephanie L. Arata Attorney-in-Fact 2015-11-13