X0306 4 2015-05-19 0 0001130591 XENOPORT INC XNPT 0001296771 Freund John Gordon C/O XENOPORT, INC. 3410 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 0 0 0 Common Stock 2015-05-19 4 M 0 5000 0.00 A 13899 D Common Stock 489469 I Through Fund Common Stock 3080 I Beneficial Ownership Common Stock 22633 I Beneficial Ownership Common Stock 3645 I Beneficial Ownership Common Stock 21200 I Beneficial Ownership Common Stock 27 I Beneficial Ownership Non-Employee Restricted Stock Units 2015-05-19 4 M 0 5000 0.00 D Common Stock 5000 0 D Non-Employee Stock Options 6.04 2015-05-19 4 A 0 15000 0.00 A 2025-05-19 Common Stock 15000 15000 D Non-Employee Restricted Stock Units 2015-05-19 4 A 0 5000 0.00 A Common Stock 5000 5000 D These shares are held by multiple entities. 22 shares are held by Skyline Venture Partners III, L.P., 887 shares are held by Skyline Venture Partners Qualified Purchasers Fund III, L.P., 227 shares are held by Skyline Venture Management III, L.L.C. and 488,333 shares are held by Skyline Venture Partners V, L.P. John G. Freund is connected to each of these entities as managing director or managing member either directly or through indirect ownership and in such capacity may be deemed to have voting and investment power with respect to shares held by each of these entities. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therin. The shares are held by John G. Freund as custodian for his two sons. The shares are owned by a retirement account of which John G. Freund is the beneficiary. The shares are held by the Paul Brooke 1989 Insurance Trust of which John G. Freund is a trustee. The shares are owned by a revocable trust of which John G. Freund is a trustee. The shares are held by John G. Freund Family Partnership IV, L.P. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therin. Each restricted stock unit represents a contingent right to receive one share of XenoPort, Inc. common stock. The restricted stock units shall cliff vest in full on earlier of the one-year anniversary of the grant date, June 17, 2014, or the next annual meeting of the company. The next annual meeting occurred on May 19, 2015. The shares shall vest and become exercisable in a series of 12 successive equal monthly installments measured from the grant date, May 19, 2015. The restricted stock units shall cliff vest in full on earlier of the one-year anniversary of the grant date, May 19, 2015, or the next annual meeting of the company. /s/ Stephanie L. Arata Attorney-in-fact 2015-05-21