X0306 4 2014-06-23 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001296771 Freund John Gordon 480 ARSENAL ST, SUITE 110 WATERTOWN MA 02472 1 0 0 0 Common Stock 2014-06-23 4 S 0 47184 13.7735 D 1690146 I By Skyline Venture Management IV, LLC The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2014. The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $13.55 to $13.93 per share. The reporting person hereby undertakes, upon request of the staff of the U.S. Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. The shares are held by Skyline Venture Partners Qualified Purchaser Fund IV, L.P. ("SVP IV"). The reporting person is a member of Skyline Venture Management IV, LLC, which serves as the sole general partner of SVP IV, and may be deemed to share voting and dispositive power over the shares held by SVP IV, however, the reporting person disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein. /s/ David C. Lubner (as attorney-in-fact for John Freund) 2014-06-25