X0306 4 2014-05-14 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001296771 Freund John Gordon 525 UNIVERSITY AVENUE SUITE 610 PALO ALTO CA 94301 1 0 0 0 Common Stock 2014-05-14 4 J 0 4493 0.00 D 0 I see footnote 2 Common Stock 2014-05-14 4 J 0 3006 0.00 A 3006 I see footnote 3 Represents a pro-rata in-kind distribution by Skyline Venture Management IV, LLC ("SVM IV") without consideration to its members. The shares are held by SVM IV. The reporting person is a member of SVM IV and may be deemed to share voting and dispositive power over the shares, however, the reporting person disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein. The shares are held by John G. Freund as Trustee of the John G. Freund Revocable Trust u/a/d 6/26/01 ("Freund Trust"). The reporting person is a trustee of Freund Trust. /s/ Karensa Kenny as attorney-in-fact 2014-05-16