X0303 4 2010-11-12 0 0001130591 XENOPORT INC XNPT 0001296771 Freund John Gordon 525 UNIVERSITY AVENUE, STE. 520 C/O SKYLINE VENTURES PALO ALTO CA 94301 1 0 0 0 Common stock 2010-11-12 4 J 0 9090 0.00 D 587226 I Through fund Common stock 2010-11-12 4 J 0 27 0.00 A 27 I Beneficial Ownership Common stock 2010-11-12 4 J 0 1179 0.00 A 3899 D On November 12, 2010, Skyline Venture Management II, L.L.C. distributed 9,090 shares of XenoPort, Inc. These shares are held by multiple entities. 103,377 are held by Skyline Expansion Fund, L.P., ten are held by Skyline Venture Partners III, L.P., 403 are held by Skyline Venture Partners Qualified Purchaser Fund III, L.P., 103 are held by Skyline Venture Management III, L.L.C. and 483,333 are held by Skyline Venture Partners V, L.P. John G. Freund is connected to each of these entities as managing director or managing member either directly or through indirect ownership and in such capacity may be deemed to have voting and investment power with respect to shares held by each of these entities. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therein. Shares received pursuant to a distribution from Skyline Venture Management II, L.L.C. The shares are held by John G. Freund Family Partnership IV, L.P. John G. Freund disclaims beneficial ownership of such securities, except to the extent of his proportionate partnership interest therein. /s/ Martyn J. Webster Attorney-in-fact 2010-11-12