X0202 4 2008-03-14 0 0001130591 XENOPORT INC XNPT 0001296771 Freund John Gordon 525 UNIVERSITY AVENUE C/O SKYLINE VENTURES PALO ALTO CA 94301 1 0 0 0 Common stock 2008-03-14 4 P 0 1698 42.05 A 14898 I Beneficial Ownership Common stock 2008-03-14 4 P 0 1200 41.43 A 16098 I Beneficial Ownership Common stock 2008-03-14 4 P 0 480 41.43 A 16578 I Beneficial Ownership Common stock 2008-03-14 4 P 0 745 41.24 A 17323 I Beneficial Ownership Common stock 2008-03-14 4 P 0 735 42.03 A 18058 I Beneficial Ownership Common stock 2008-03-14 4 P 0 2720 41.43 A 2720 D Common stock 704924 I Through Fund The shares are owned by a retirement account of which John Freund is the beneficiary. The shares are owned by a revocable trust of which John Freund is a trustee. The shares are held by John Freund as custodian for his two sons. The shares are held by the Paul Brooke 1989 Insurance Trust of which John Freund is a trustee. Includes 3,080 shares held by John Freund as custodian for his two sons, 10,133 shares owned by retirement accounts of which he is the beneficiary, 3,645 shares held by the Paul Brooke 1989 Insurance Trust of which he is a trustee and 1,200 shares owned by a revocable trust of which he is also a trustee. These shares are held by multiple entities. 47,269 are held by Skyline Venture Partners II, LP, 550,662 are held by Skyline Venture Partners Qualified Purchasers Fund II, LP, 103,377 are held by Skyline Expansion Fund, LP, 3,100 are held by Skyline Venture Management II, LLC, 10 are held by Skyline Venture Partners III, LP, 403 are held by Skyline Venture Partners Qualified Purchasers Fund III, LP and 103 are held by Skyline Venture Management III, LLC. John G. Freund is connected to each of these entities as managing director or managing member either directly or through indirect ownership and in such capacity may be deemed to have voting and investment power with respect to shares held by each of these entities. John G. Freund disclaims beneficial ownership of such securities except to the extent of his proportionate partnership interest therein. /s/ Martyn J Webster Attorney-in-fact 2008-03-18