X0202 4 2005-09-13 0 0001130591 XENOPORT INC XNPT 0001296771 Freund John Gordon 125 UNIVERSITY AVENUE C/O SKYLINE VENTURES PALO ALTO CA 94301 1 0 0 0 Common Stock 2005-09-13 4 P 0 1600 15.10 A 1107959 I Through Fund Common Stock 2005-09-13 4 P 0 100 15.08 A 1108059 I Through Fund Common Stock 2005-09-13 4 P 0 300 15.07 A 1108359 I Through Fund Common Stock 2005-09-13 4 P 0 1000 15.25 A 1109359 I Through Fund Common Stock 2005-09-13 4 P 0 1200 15.0708 A 1110559 I Through Fund 600 shares were purchased by John G. Freund as custodian for Alexander Freund and 600 shares were purchased by John G. Freund as custodian for Nicholas Freund. These shares are held by multiple entities. 71,795 shares are held by Skyline Venture partners II, LP 836,365 shares are held by Skyline Venture Partners Qualified Purchaser Fund II LP and 189,199 shares are held by Skyline Expansion Fund LP. Skyline Venture Management II, LLC is the general partner of each of these funds. John G. Freund is one of the Managing Directors of Skyline Venture Management II and in such capacity may be deemed to have voting and investment power with respect to shares held by both Skyline Venture partners II, LP, Skyline Venture Partners Qualified Purchaser Fund II LP and Skyline Expansion Fund LP. John G. Freund disclaims beneficial ownership of such securities except to the extent of his proportionate partnership interest therein. 11,300 shares are held by John G. Freund, of which 2,600 are held as custodian for his sons, Alexander and Nicholas Freund. 1,900 shares are held by the Paul Brooke Trust of which John G Freund is a trustee. /s/Martyn J. Webster, Attorney-in-fact 2005-09-15