X0306 4 2022-01-15 0 0001278021 MARKETAXESS HOLDINGS INC MKTX 0001296466 McVey Richard M C/O MARKETAXESS HOLDINGS INC. 55 HUDSON YARDS, 15TH FLOOR NEW YORK NY 10001 1 1 0 0 Chairman & CEO Common Stock, par value $0.003 per share 2022-01-15 4 F 0 6810 371.54 D 729833 D Common Stock, par value $0.003 per share 2000 I By Immediate Family Members Represents the surrender of shares to the Company to satisfy Mr. McVey's tax withholding obligation upon the receipt of vested restricted stock units that had been previously deferred by Mr. McVey. /s/ Jason Edelstein, as Attorney-in-Fact for Richard M. McVey 2022-01-19