144 0001295913 XXXXXXXX LIVE 0001579428 Axsome Therapeutics, Inc. 001-37635 ONE WORLD TRADE CENTER, 29TH FLOOR NEW YORK NY 10007 (212) 332-3241 Saad Mark E Director Common Charles Schwab & Co., Inc.

3000 Schwab Way Westlake TX 76262

37577 6206927.00 50412640 12/31/2025 NASDAQ Common 12/31/2025 Employee Stock Option Exercise Axsome Therapeutics, Inc. N 37577 12/31/2025 Broker Payment for Cashless Exercise Y 12/31/2025 09/11/2025 MARK E SAAD