X0206 3 2020-04-30 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001439589 Polaris Venture Management Co. V, L.L.C. ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001439586 Polaris Venture Partners Special Founders' Fund V, L.P. ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON 02210 0 0 1 0 0001439590 Polaris Venture Partners V, L.P. ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001439587 Polaris Venture Partners Entrepreneurs' Fund V, L.P. ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001439588 Polaris Venture Partners Founders' Fund V, L.P. ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001117003 MCGUIRE TERRANCE ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001295676 Flint Jonathan A ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 Series A-1/C Convertible Preferred Stock Common Stock 181790 I See footnote Series A-1/C Convertible Preferred Stock Common Stock 3543 I See footnote Series A-1/C Convertible Preferred Stock Common Stock 1817 I See footnote Series A-1/C Convertible Preferred Stock Common Stock 1245 I See footnote Series A-2 Convertible Preferred Stock Common Stock 95583 I See footnote Series A-2 Convertible Preferred Stock Common Stock 1862 I See footnote Series A-2 Convertible Preferred Stock Common Stock 955 I See footnote Series A-2 Convertible Preferred Stock Common Stock 654 I See footnote Series A-3 Convertible Preferred Stock Common Stock 249690 I See footnote Series A-3 Convertible Preferred Stock Common Stock 4866 I See footnote Series A-3 Convertible Preferred Stock Common Stock 2496 I See footnote Series A-3 Convertible Preferred Stock Common Stock 1710 I See footnote Series A-4 Convertible Preferred Stock Common Stock 223107 I See footnote Series A-4 Convertible Preferred Stock Common Stock 4348 I See footnote Series A-4 Convertible Preferred Stock Common Stock 2231 I See footnote Series A-4 Convertible Preferred Stock Common Stock 1528 I See footnote Series B Convertible Preferred Stock Common Stock 186131 I See footnote Series B Convertible Preferred Stock Common Stock 3627 I See footnote Series B Convertible Preferred Stock Common Stock 1861 I See footnote Series B Convertible Preferred Stock Common Stock 1275 I See footnote Series C Convertible Preferred Stock Common Stock 57680 I See footnote Series C Convertible Preferred Stock Common Stock 1124 I See footnote Series C Convertible Preferred Stock Common Stock 576 I See footnote Series C Convertible Preferred Stock Common Stock 395 I See footnote Common Warrants 8.63 2020-01-10 2030-01-10 Common Stock 17304 I See footnote Common Warrants 8.63 2020-01-10 2030-01-10 Common Stock 337 I See footnote Common Warrants 8.63 2020-01-10 2030-01-10 Common Stock 173 I See footnote Common Warrants 8.63 2020-01-10 2030-01-10 Common Stock 118 I See footnote The preferred stock is convertible at any time, at the holder's election and has no expiration date. Each share of preferred stock shall be automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The reportable securities are owned directly by Polaris Venture Partners V, L.P. ("PVP V"). Polaris Venture Management Co. V, L.L.C. ("PVM V") is the general partner of PVP V. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM V and may be deemed to have shared voting and dispositive power over the shares held by PVP V. Each of PVM V, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPE V"). PVM V is the general partner of PVPE V. Each of Flint and McGuire are the managing members of PVM V and may be deemed to have shared voting and dispositive power over the shares held by PVPE V. Each of PVM V, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V"). PVM V is the general partner of PVPSFF V. Each of Flint and McGuire are the managing members of PVM V and may be deemed to have shared voting and dispositive power over the shares held by PVPSFF V. Each of PVM V, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"). PVM V is the general partner of PVPFF V. Each of Flint and McGuire are the managing members of PVM V and may be deemed to have shared voting and dispositive power over the shares held by PVPFF V. Each of PVM V, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. Flint and McGuire are also the managing members of Polaris Venture Management Co. IV, L.L.C., the sole general partner of each of Polaris Venture Partners IV, L.P. and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. Due to limitations of the EDGAR filing system, this report on Form 3 is one of two reports which are being filed to enable all joint filers to gain access to the EDGAR filing system. /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Special Founders' Fund V, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners V, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Entrepreneurs' Fund V, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. V, L.L.C., general partner of Polaris Venture Partners Founders' Fund V, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Terrance G. McGuire 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Jonathan A. Flint 2020-04-30