X0206 3 2020-04-30 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001295438 Polaris Venture Management Co IV LLC ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001170720 POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 0001157864 POLARIS VENTURE PARTNERS IV LP ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON MA 02210 0 0 1 0 Series A-1/A Convertible Preferred Stock Common Stock 98213 I See footnote Series A-1/A Convertible Preferred Stock Common Stock 1841 I See footnote Series A-1/B Convertible Preferred Stock Common Stock 93808 I See footnote Series A-1/B Convertible Preferred Stock Common Stock 1758 I See footnote Series A-2 Convertible Preferred Stock Common Stock 100963 I See footnote Series A-2 Convertible Preferred Stock Common Stock 1892 I See footnote Series A-3 Convertible Preferred Stock Common Stock 23996 I See footnote Series A-3 Convertible Preferred Stock Common Stock 449 I See footnote The preferred stock is convertible at any time, at the holder's election and has no expiration date. Each share of preferred stock shall be automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. Flint and McGuire are also the managing members of Polaris Venture Management Co. V, L.L.C., which is the sole general partner of each of Polaris Venture Partners V, L.P., Polaris Venture Partners Entrepreneurs' Fund V, L.P., Polaris Venture Partners Founders' Fund V, L.P., and Polaris Venture Partners Special Founders' Fund V, L.P. Due to limitations of the EDGAR filing system, this report on Form 3 is one of two reports which are being filed to enable all joint filers to gain access to the EDGAR filing system. /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C., general partner of Polaris Venture Partners Entrepreneurs' Fund IV, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C., general partner of Polaris Venture Partners IV, L.P. 2020-04-30 /s/ Lauren Crockett, Attorney-in-Fact for Polaris Venture Management Co. IV, L.L.C 2020-04-30