<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-11-10</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001251769</issuerCik>
        <issuerName>LPATH, INC</issuerName>
        <issuerTradingSymbol>LPTN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001294939</rptOwnerCik>
            <rptOwnerName>Petree Daniel H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O LPATH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>6335 FERRIS SQUARE, SUITE A</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO, CALIFORNIA</rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>/s/ Daniel Petree</signatureName>
        <signatureDate>2008-11-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
