X0202 4 2004-06-02 0 0001145404 CRITICAL THERAPEUTICS INC CRTX 0001291804 George Jean C/O CRITICAL THERAPEUTICS, INC. 60 WESTVIEW ROAD LEXINGTON MA 02421 1 0 1 0 0001294514 Advanced Technology Ventures VI, L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 0001294521 ATV Entrepreneurs VI, L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 0001294971 ATV Alliance 2003, L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 0001294513 ATV Entrepreneurs VII, L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 0001138942 ADVANCED TECHNOLOGY VENTURES VII LP 281 WINTER ST SUITE 350 WALTHAM MA 02451 0 0 1 0 0001294525 Advanced Technology Ventures VII(B), L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 0001294527 Advanced Technology Ventures VII(C), L.P. 1000 WINTER STREET, SUITE 3700 WALTHAM MA 02451 0 0 1 0 Common Stock 2004-06-02 4 C 0 1904759 0 A 1904759 I See Footnote Series B Convertible Preferred Stock 2004-06-02 4 C 0 7142856 0 D Common Stock 1904759 0 I See Footnote Automatic conversion of every 3.75 shares of Series B Convertible Preferred Stock into 1 share of Common Stock upon the closing of the Issuer's initial public offering. The shares are held as follows: 1,527,100 by ATV VII, 61,281 by Advanced Technology Ventures VII(B), L.P., 29,456 by Advanced Technology Ventures VII(C), L.P., 9,100 by ATV Entrepreneurs VII, L.P., 5,714 by ATV Alliance 2003, L.P., 255,782 by Advanced Technology Ventures VI, L.P. and 16,326 by ATV Entrepreneurs VI, L.P. These shares are held directly by the Funds which are managed by their respective General Partners. Ms. George is a managing director of the General Partner of ATV VII and its affiliated funds. Ms. George disclaims beneficial ownership of the shares held by the Funds, except to the extent of her pecuniary interest therein. This Form 4 is filed by Jean George ("Ms. George") and Advanced Technology Ventures VII, L.P. ("ATV VII"), Advanced Technology Ventures VII(B), L.P., Advanced Technology Ventures VII(C), L.P., ATV Entrepreneurs VII, L.P., ATV Alliance 2003, L.P., Advanced Technology Ventures VI, L.P. and ATV Entrepreneurs VI, L.P. (collectively, the "Funds"). Ms. George and the Funds are sometimes referred to herein as the "Reporting Person." The address of the principal business office of each of the Reporting Persons is 1000 Winter Street, Suite 3700, Waltham, MA 02451. By: /s/ Jean M. George 2004-06-04 Advanced Technology Ventures VII, L.P. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04 Advanced Technology Ventures VII(B), L.P. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04 Advanced Technology Ventures VII(C), L.P. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04 ATV Entrepreneurs VII, L.L.C. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04 ATV Alliance 2003, L.L.C. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04 Advanced Technology Ventures VI, L.P. By: ATV Associates VI, L.L.C. By: /s/ Wesley Raffel 2004-06-04 ATV Entrepreneurs VI, L.L.C. By: ATV Associates VII, L.L.C. By: /s/ Wesley Raffel 2004-06-04