144 0001294192 XXXXXXXX LIVE 0001628171 Revolution Medicines, Inc. 001-39219 700 Saginaw Drive Redwood City CA 94063 4157663638 Horn Margaret A Officer Common Stock ETRADE Financial Corporation

3 Edison Drive Alpharetta GA 30005

3486 536390.82 212596462 06/15/2026 NASDAQ Common Stock 03/01/2023 Restricted stock unit grant Issuer N 1272 03/01/2023 Services Rendered Common Stock 03/01/2024 Restricted stock unit grant Issuer N 1304 03/01/2024 Services Rendered Common Stock 03/01/2025 Restricted stock unit grant Issuer N 910 03/01/2025 Services Rendered N Margaret A. Horn

c/o Revolution Medicines, Inc. 700 Saginaw Drive Redwood City CA 94063

Common Stock 03/17/2026 4583 455918.67 Margaret A. Horn

c/o Revolution Medicines, Inc. 700 Saginaw Drive Redwood City CA 94063

Common Stock 06/11/2026 10000 1480140.00 06/15/2026 05/31/2023 Jack Anders, as Attorney-in-Fact for Margaret A. Horn