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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Revenue:        
Total revenues $ 13,296 $ 7,851 $ 25,767 $ 23,808
Operating expenses:        
Research and development 146,540 115,014 269,180 212,123
General and administrative 68,631 41,168 128,910 76,094
Cost of license and royalty revenue $ 613 $ 21 $ 1,043 $ 36
Type of cost, good or service [Extensible List] blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember
Change in fair value of contingent consideration $ 214 $ 262 $ 510 $ 796
Total operating expenses 215,998 156,465 399,643 289,049
Loss from operations (202,702) (148,614) (373,876) (265,241)
Interest income, net 9,387 2,436 19,489 3,824
Other (expense) income, net (2,936) 182 (6,325) 297
Loss before income taxes (196,251) (145,996) (360,712) (261,120)
Income tax benefit 469   484  
Net loss $ (195,782) $ (145,996) $ (360,228) $ (261,120)
Net loss per share - basic and diluted: $ (3.55) $ (2.91) $ (6.54) $ (5.22)
Weighted-average number of common shares used in computing net loss per share - basic and diluted: 55,165 50,153 55,062 50,038
Other comprehensive income (loss):        
Other comprehensive income (loss), net of tax expense of $0.8 million and $0.0 million for the three months ended June 30, 2019 and 2018, respectively, and $1.3 million and $0.0 million for the six months ended June 30, 2019 and 2018, respectively $ 973 $ (345) $ 2,808 $ (1,189)
Total other comprehensive income (loss) 973 (345) 2,808 (1,189)
Comprehensive loss (194,809) (146,341) (357,420) (262,309)
Collaboration [Member]        
Revenue:        
Total revenues 11,558 7,437 22,735 23,045
License and Royalty [Member]        
Revenue:        
Total revenues $ 1,738 $ 414 $ 3,032 $ 763