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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenue:    
Total revenues $ 12,471 $ 15,957
Operating expenses:    
Research and development 122,640 97,109
General and administrative 60,279 34,926
Cost of license and royalty revenue $ 430 $ 17
Type of cost, good or service [Extensible List] blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember
Change in fair value of contingent consideration $ 296 $ 534
Total operating expenses 183,645 132,586
Loss from operations (171,174) (116,629)
Interest income, net 10,102 1,388
Other (expense) income, net (3,389) 115
Loss before income taxes (164,461) (115,126)
Income tax benefit 15  
Net loss $ (164,446) $ (115,126)
Net loss per share - basic and diluted: $ (2.99) $ (2.31)
Weighted-average number of common shares used in computing net loss per share - basic and diluted: 54,957 49,923
Other comprehensive income (loss):    
Other comprehensive income (loss), net of tax expense of $0.4 million and $0.0 million for the three months ended March 31, 2019 and 2018, respectively $ 1,835 $ (844)
Total other comprehensive income (loss) 1,835 (844)
Comprehensive loss (162,611) (115,970)
Collaboration [Member]    
Revenue:    
Total revenues 11,177 15,608
License and Royalty [Member]    
Revenue:    
Total revenues $ 1,294 $ 349