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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Revenue:        
Total revenues $ 11,528 $ 7,711 $ 35,336 $ 31,259
Operating expenses:        
Research and development 116,744 61,545 328,867 180,464
General and administrative 44,527 22,982 120,621 64,463
Cost of license and royalty revenue $ 29 $ 1,100 $ 67 $ 1,520
Type of cost, good or service [Extensible List] blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember blue:LicenseAndRoyaltyMember
Change in fair value of contingent consideration $ 47 $ (258) $ 843 $ 205
Total operating expenses 161,347 85,369 450,398 246,652
Loss from operations (149,819) (77,658) (415,062) (215,393)
Interest income (expense), net 4,591 (1,155) 8,415 (1,842)
Other income (expense), net (252) 8 45 (1,180)
Loss before income taxes (145,480) (78,805) (406,602) (218,415)
Net loss $ (145,480) $ (78,805) $ (406,602) $ (218,415)
Net loss per share - basic and diluted: $ (2.73) $ (1.73) $ (7.95) $ (5.14)
Weighted-average number of common shares used in computing net loss per share - basic and diluted: 53,277 45,648 51,130 42,524
Other comprehensive loss:        
Other comprehensive loss, net of tax expense of $0.0 and $0.0 million for the three and nine months ended September 30, 2018 and 2017, respectively $ (66) $ (683) $ (1,255) $ (949)
Total other comprehensive loss (66) (683) (1,255) (949)
Comprehensive loss (145,546) (79,488) (407,857) (219,364)
Collaboration [Member]        
Revenue:        
Total revenues 10,926 5,211 33,971 18,189
License and Royalty [Member]        
Revenue:        
Total revenues $ 602 $ 2,500 $ 1,365 $ 13,070