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Basis of presentation, principles of consolidation and significant accounting policies (Tables)
 9 Months Ended
Sep. 30, 2018
Statement of Reconciliation of Cash Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash within the statement of financial position that sum to the total of the same such amounts shown in the statement of cash flows:

 

(in thousands)

As of

September 30,

2018

 

 

As of

September 30,

2017

 

Cash and cash equivalents

$

952,137

 

 

$

237,962

 

Restricted cash included in receivables and other current assets

 

100

 

 

 

—

 

Restricted cash included in restricted cash and other non-current assets

 

13,763

 

 

 

13,762

 

Total cash, cash equivalents, and restricted cash shown in the statement

   of cash flows

$

966,000

 

 

$

251,724

 

 
ASU 2014-09 [Member]  
Summary of Impact of Topic 606 Adoption on Financial Statement

Refer below for a summary of the amount by which each financial statement line item was affected by the impact of the cumulative adjustment:

 

 

Impact of Topic 606 adoption on

condensed consolidated balance sheet

as of January 1, 2018

 

(in thousands)

As reported under

Topic 606

 

 

Adjustments

 

 

Balances without

adoption of

Topic 606

 

Deferred revenue, current portion

$

45,344

 

 

$

19,670

 

 

$

25,674

 

Deferred revenue, net of current portion

$

31,468

 

 

$

9,705

 

 

$

21,763

 

Accumulated deficit

$

(943,183

)

 

$

(29,375

)

 

$

(913,808

)

 

The amount by which each financial statement line item is affected in the current reporting period by Topic 606 as compared with the guidance that was in effect prior to adoption is disclosed below.

 

 

Impact of Topic 606 adoption on

condensed consolidated balance sheet

as of September 30, 2018

 

(in thousands)

As reported under

Topic 606

 

 

Adjustments

 

 

Balances without

adoption of

Topic 606

 

Deferred revenue, current portion

$

22,575

 

 

$

9,596

 

 

$

12,979

 

Deferred revenue, net of current portion

$

22,256

 

 

$

6,074

 

 

$

16,182

 

Accumulated deficit

$

(1,349,785

)

 

$

15,670

 

 

$

(1,365,455

)

 

 

 

Impact of Topic 606 adoption on condensed consolidated

statement of operations and comprehensive loss

for the three months ended September 30, 2018

 

(in thousands, except per share data)

As reported under

Topic 606

 

 

Adjustments

 

 

Balances without

adoption of

Topic 606

 

Collaboration revenue

$

10,926

 

 

$

2,097

 

 

$

8,829

 

Research and development expense

$

116,744

 

 

$

(2,789

)

 

$

119,533

 

Net loss

$

(145,480

)

 

$

4,886

 

 

$

(150,366

)

Net loss per share - basic and diluted:

$

(2.73

)

 

$

0.09

 

 

$

(2.82

)

 

 

 

 

 

 

 

 

 

 

 

 

 

Impact of Topic 606 adoption on condensed consolidated

statement of operations and comprehensive loss

for the nine months ended September 30, 2018

 

(in thousands, except per share data)

As reported under

Topic 606

 

 

Adjustments

 

 

Balances without

adoption of

Topic 606

 

Collaboration revenue

$

33,971

 

 

$

9,116

 

 

$

24,855

 

Research and development expense

$

328,867

 

 

$

(4,589

)

 

$

333,456

 

Net loss

$

(406,602

)

 

$

13,705

 

 

$

(420,307

)

Net loss per share - basic and diluted:

$

(7.95

)

 

$

0.27

 

 

$

(8.22

)

 

 

 

Impact of Topic 606 adoption on

condensed consolidated statement of cash flows

for the nine months ended September 30, 2018

 

(in thousands)

As reported under

Topic 606

 

 

Adjustments

 

 

Balances without

adoption of

Topic 606

 

Net loss

$

(406,602

)

 

$

13,705

 

 

$

(420,307

)

Changes in deferred revenue

$

(31,981

)

 

$

(13,705

)

 

$

(18,276

)