Property, plant and equipment, net

9 Months Ended

Sep. 30, 2018

Property Plant And Equipment [Abstract]

6. Property, plant and equipment, net

Property, plant and equipment, net, consists of the following (in thousands):

	As of			As of
	September 30, 2018			December 31, 2017
Land	$	1,210		$	1,210
Building		179,754			164,414
Computer equipment and software		6,790			5,134
Office equipment		5,371			4,478
Laboratory equipment		32,159			24,914
Leasehold improvements		115			116
Construction-in-progress		33,103			15,189
Total property, plant and equipment		258,502			215,455
Less accumulated depreciation and amortization		(25,639	)		(15,849	)
Property, plant and equipment, net	$	232,863		$	199,606

North Carolina manufacturing facility

In November 2017, the Company acquired a manufacturing facility, which is in the process of construction, in Durham, North Carolina for the future manufacture of lentiviral vector for the Company’s gene therapies. Construction-in-progress as of September 30, 2018 and December 31, 2017 includes $27.3 million and $12.9 million, respectively, related to the North Carolina manufacturing facility. During the three months ended September 30, 2018, the Company placed $12.2 million of the North Carolina manufacturing facility into service and began to depreciate the assets.

60 Binney Street lease

As of September 30, 2018, total property, plant and equipment, gross, includes $167.6 million related to the Company’s headquarters at 60 Binney Street in Cambridge, Massachusetts, of which $156.0 million was incurred by the landlord. As of December 31, 2017, total property, plant and equipment, gross, includes $164.4 million related to the Company’s headquarters at 60 Binney Street in Cambridge, Massachusetts, of which $156.0 million was incurred by the landlord. Please refer to Note 8, "Commitments and contingencies" for further information.