Selected quarterly financial data (Unaudited) (Tables)

12 Months Ended

Dec. 31, 2016

Quarterly Financial Information Disclosure [Abstract]

Quarterly Financial Information

The following table contains quarterly financial information for 2016 and 2015. The Company believes that the following information reflects all normal recurring adjustments necessary for a fair presentation of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period.

	2016
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Total
	(in thousands, except per share data)
Total revenue	$	1,499		$	1,552		$	1,552		$	1,552		$	6,155
Total operating expenses		58,879			61,527			79,692			73,887			273,985
Loss from operations		(57,380	)		(59,975	)		(78,140	)		(72,335	)		(267,830	)
Net loss		(56,274	)		(58,844	)		(77,025	)		(71,364	)		(263,507	)
Net loss per share applicable to common stockholders - basic and diluted	$	(1.52	)	$	(1.59	)	$	(2.07	)	$	(1.88	)	$	(7.07	)

	2015
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Total
	(in thousands, except per share data)
Total revenue	$	6,344		$	4,940		$	1,324		$	1,471		$	14,079
Total operating expenses		31,270			56,963			44,451			50,432			183,116
Loss from operations		(24,926	)		(52,023	)		(43,127	)		(48,961	)		(169,037	)
Net loss		(24,787	)		(51,795	)		(42,924	)		(47,277	)		(166,783	)
Net loss per share applicable to common stockholders - basic and diluted	$	(0.76	)	$	(1.57	)	$	(1.18	)	$	(1.29	)	$	(4.81	)