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Stock-based compensation (Tables)
 9 Months Ended
Sep. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense recognized by award type is included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended September 30,For the nine months ended September 30,

2024202320242023
Stock options$920 $1,758 $3,343 $5,192 
Restricted stock units1,755 2,916 6,217 10,552 
Employee stock purchase plan and other26 194 109 269 
$2,701 $4,868 $9,669 $16,013 
Schedule of Stock-Based Compensation Expense by Classification
Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended September 30,For the nine months ended September 30,
2024202320242023
Cost of product revenue102 342 882 435 
Selling, general and administrative1,650 2,461 5,783 7,503 
Research and development681 2,065 2,736 8,075 
Restructuring Expenses268 — 268 — 
$2,701 $4,868 $9,669 $16,013 
Summary of Stock Option Activity Under Plan
The following table summarizes the stock option activity under the Company’s equity award plans excluding awards held by employees of 2seventy bio:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20234,227 $14.16 
Granted3,010 $1.47 
Exercised— $— 
Canceled, forfeited, or expired(905)$10.52 
Outstanding at September 30, 20246,332 $8.66 
Exercisable at September 30, 20242,290 $18.54 
Vested and expected to vest at September 30, 20246,332 $8.66 
Summary of Restricted Common Stock Awards
The following table summarizes the restricted stock unit activity under the Company’s equity award plans excluding awards held by employees of 2seventy bio:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested at December 31, 20234,207 $6.08 
Granted3,357 $1.23 
Vested(1,083)$7.08 
Forfeited(907)$4.05 
Unvested at September 30, 20245,574 $3.29