Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Cash flows from operating activities:
Net loss	$ (211,913)	$ (230,342)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	28,525	8,344
Stock-based compensation expense	19,429	35,090
Noncash research and development expense (finance lease)	21,198	11,180
Noncash operating lease expense	29,772	23,562
Loss on fixed assets disposal	(92,930)	(102,000)
Unrealized loss (gain) on equity securities	0	3,135
Excess inventory reserve	15,363	7,519
Other non-cash items	24	4,138
Gain on foreign currency exchange rates	167	(1,801)
Proceeds from sale of accounts receivable	5,040	0
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(3,894)	(4,820)
Inventory	(36,560)	(7,227)
Operating lease right-of-use assets		0
Accounts payable	2,841	(7,709)
Operating lease liabilities	(28,887)	(14,072)
Accrued expenses and other liabilities	13,353	(45,974)
Accrued interest payable under finance lease	3,426	4,758
Net cash used in operating activities	(235,046)	(316,219)
Cash flows from investing activities:
Purchase of property, plant and equipment	(4,189)	(8,208)
Purchases of marketable securities	(43,297)	0
Proceeds from maturities of marketable securities	108,521	131,445
Proceeds from sales of marketable securities	5,853	30,216
Purchase of intangible assets	(4,868)	(5,000)
Proceeds from sale of priority review voucher	92,930	102,000
Net cash provided by investing activities	154,950	250,453
Cash flows from financing activities:
Proceeds from public offering of common stock, net of issuance costs	248,198	54,237
Proceeds from the transfer of invoices	2,520	0
Principal payments on finance leases	(54,367)	(36,734)
Other financing activities	(103)	16
Net cash provided by financing activities	196,248	17,519
Increase (decrease) in cash, cash equivalents and restricted cash	116,152	(48,247)
Cash, cash equivalents and restricted cash at beginning of year	158,445	206,692
Cash, cash equivalents and restricted cash at end of year	274,597	158,445
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	221,755	113,006
Restricted cash included in receivables and other current assets	9,202	1,502
Restricted cash included in restricted cash and other non-current assets	43,640	43,937
Total cash, cash equivalents and restricted cash	274,597	158,445
Supplemental cash flow disclosures:
Right-of-use assets obtained in exchange for operating lease liabilities	(708)	221,036
Purchases of property, plant and equipment included in accounts payable and accrued expenses	884	(3)
Purchases of intangible assets included in accrued expenses	1,221	0
Right-of-use assets obtained in exchange for finance lease liabilities	21,929	73,443
Offering expenses included in accounts payable and accrued expenses	964	170
Beneficiary interest obtained in transferred invoices	560	0
Cash paid (refunded) during the period for income taxes	$ (42)	$ 253