Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows from operating activities:
Net income (loss)	$ (123,399)	$ (298,810)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	3,124	3,745
Stock-based compensation expense	16,013	30,509
Gain from sale of priority review voucher	(92,930)	0
Loss (gain) on equity securities	0	3,135
Excess inventory reserve	5,333	7,519
Other non-cash items	19	2,890
Changes in operating assets and liabilities:
Accounts receivable	(23,000)	0
Prepaid expenses and other assets	(523)	(6,197)
Inventory	(24,931)	0
Operating lease right-of-use assets	40,101	29,650
Accounts payable	(5,787)	(7,552)
Accrued expenses and other liabilities	7,125	(39,046)
Operating lease liabilities	(30,506)	(22,523)
Deferred revenue	8,152	0
Net cash used in operating activities	(221,209)	(296,680)
Cash flows from investing activities:
Purchase of property, plant and equipment	(2,975)	(8,100)
Purchases of marketable securities	(43,297)	0
Proceeds from maturities of marketable securities	99,521	125,095
Proceeds from sales of marketable securities	5,853	30,216
Purchase of intangible assets	(868)	0
Proceeds from sale of priority review voucher	92,930	0
Net cash provided by investing activities	151,164	147,211
Cash flows from financing activities:
Proceeds from exercise of stock options and ESPP contributions	93	3
Net cash provided by financing activities	129,969	54,368
(Decrease) increase in cash, cash equivalents and restricted cash	59,924	(95,101)
Cash, cash equivalents and restricted cash at beginning of period	158,445	206,693
Cash, cash equivalents and restricted cash at end of period	218,369	111,592
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	165,347	66,478
Restricted cash included in other current assets	8,885	1,565
Restricted cash included in restricted cash and other non-current assets	44,137	43,549
Total cash, cash equivalents and restricted cash	218,369	111,592
Supplemental cash flow disclosures from investing and financing activities:
Purchases of property, plant and equipment included in accounts payable and accrued expenses	941	176
Offering expenses accrued or in accounts payable	248	298
Right-of-use assets obtained in exchange for operating lease liabilities	44,819	229,636
Increase (Reduction) of right of use asset and associated lease liability due to lease reassessment	8,003	(2,833)
Cash paid during the period for income taxes	5	0
Private Placement
Cash flows from financing activities:
Proceeds from issuance of common stock	(196)	0
Public Offering
Cash flows from financing activities:
Proceeds from issuance of common stock	$ 130,072	$ 54,365