Condensed Consolidated Statements of Stockholders' Equity (unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	Common stock	Additional paid-in capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2021		71,115
Beginning balance at Dec. 31, 2021	$ 374,277	$ 711	$ 4,096,402	$ (2,911)	$ (3,719,925)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		310
Vesting of restricted stock units	0	$ 3	(3)
Exercise of stock options (in shares)		1
Exercise of stock options	1		1
Stock-based compensation	12,681		12,681
Issuance of stock awards (in shares)		12
Other comprehensive income (loss)	(1,548)			(1,548)
Net income (loss)	(122,152)				(122,152)
Ending balance, shares (in shares) at Mar. 31, 2022		71,438
Ending balance at Mar. 31, 2022	263,259	$ 714	4,109,081	(4,459)	(3,842,077)
Beginning balance (in shares) at Dec. 31, 2021		71,115
Beginning balance at Dec. 31, 2021	374,277	$ 711	4,096,402	(2,911)	(3,719,925)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Other comprehensive income (loss)	(1,719)
Net income (loss)	(298,810)
Ending balance, shares (in shares) at Sep. 30, 2022		82,880
Ending balance at Sep. 30, 2022	158,857	$ 829	4,181,393	(4,630)	(4,018,735)
Beginning balance (in shares) at Mar. 31, 2022		71,438
Beginning balance at Mar. 31, 2022	263,259	$ 714	4,109,081	(4,459)	(3,842,077)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		60
Vesting of restricted stock units	0	$ 1	(1)
Exercise of stock options (in shares)		1
Exercise of stock options	1		1
Issuance of common stock (in shares)		2,052
Issuance of common stock	8,043	$ 20	8,023
Stock-based compensation	8,908		8,908
Other comprehensive income (loss)	43			43
Net income (loss)	(100,138)				(100,138)
Ending balance, shares (in shares) at Jun. 30, 2022		73,551
Ending balance at Jun. 30, 2022	180,116	$ 735	4,126,012	(4,416)	(3,942,215)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		572
Vesting of restricted stock units	0	$ 6	(6)
Purchase of common stock under ESPP (in shares)		67
Purchase of common stock under employee stock purchase plan (ESPP)	239	$ 1	238
Issuance of common stock (in shares)		8,690
Issuance of common stock	46,024	$ 87	45,937
Stock-based compensation	9,212		9,212
Other comprehensive income (loss)	(214)			(214)
Net income (loss)	(76,520)				(76,520)
Ending balance, shares (in shares) at Sep. 30, 2022		82,880
Ending balance at Sep. 30, 2022	$ 158,857	$ 829	4,181,393	(4,630)	(4,018,735)
Beginning balance (in shares) at Dec. 31, 2022	82,923	82,923
Beginning balance at Dec. 31, 2022	$ 196,343	$ 830	4,186,086	(4,070)	(3,986,503)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		382
Vesting of restricted stock units	(195)	$ 3	(198)
Exercise of stock options (in shares)		3
Exercise of stock options	7		7
Purchase of common stock under ESPP (in shares)		62
Purchase of common stock under employee stock purchase plan (ESPP)	227	$ 1	226
Issuance of common stock (in shares)		23,000
Issuance of common stock	130,291	$ 230	130,061
Stock-based compensation	5,843		5,843
Other comprehensive income (loss)	984			984
Net income (loss)	21,240				21,240
Ending balance, shares (in shares) at Mar. 31, 2023		106,370
Ending balance at Mar. 31, 2023	$ 354,740	$ 1,064	4,322,025	(3,086)	(3,965,263)
Beginning balance (in shares) at Dec. 31, 2022	82,923	82,923
Beginning balance at Dec. 31, 2022	$ 196,343	$ 830	4,186,086	(4,070)	(3,986,503)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options (in shares)	3
Other comprehensive income (loss)	$ 1,843
Net income (loss)	$ (123,399)
Ending balance, shares (in shares) at Sep. 30, 2023	107,022	107,022
Ending balance at Sep. 30, 2023	$ 222,536	$ 1,071	4,333,594	(2,227)	(4,109,902)
Beginning balance (in shares) at Mar. 31, 2023		106,370
Beginning balance at Mar. 31, 2023	354,740	$ 1,064	4,322,025	(3,086)	(3,965,263)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		65
Vesting of restricted stock units	0	$ 1	(1)
Exercise of stock options (in shares)		19
Exercise of stock options	77		77
Stock-based compensation	6,388		6,388
Other comprehensive income (loss)	722			722
Net income (loss)	(72,908)				(72,908)
Ending balance, shares (in shares) at Jun. 30, 2023		106,454
Ending balance at Jun. 30, 2023	289,019	$ 1,065	4,328,489	(2,364)	(4,038,171)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)		566
Vesting of restricted stock units	0	$ 6	(6)
Exercise of stock options (in shares)		2
Exercise of stock options	8		8
Issuance of common stock (in shares)		0
Issuance of common stock	(50)	$ 0	(50)
Stock-based compensation	5,153		5,153
Other comprehensive income (loss)	137			137
Net income (loss)	$ (71,731)				(71,731)
Ending balance, shares (in shares) at Sep. 30, 2023	107,022	107,022
Ending balance at Sep. 30, 2023	$ 222,536	$ 1,071	$ 4,333,594	$ (2,227)	$ (4,109,902)